Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 6 of 6
Full-Text Articles in Medicine and Health Sciences
Mechanoregulation Of Leading Edge Pka Activity During Ovarian Cancer Cell Migration, Andrew J. Mckenzie
Mechanoregulation Of Leading Edge Pka Activity During Ovarian Cancer Cell Migration, Andrew J. Mckenzie
Graduate College Dissertations and Theses
Ovarian cancer is the deadliest of all the gynecologic cancers and is known for its clinically occult and asymptomatic dissemination. Most ovarian malignancies are diagnosed in the late stages of the disease and the high rate of morbidity is thought to be due, in part, to the highly metastatic nature of ovarian carcinomas. Cancer metastasis relies on the ability of cells to migrate away from primary tumors and invade into target tissues. Though the processes are distinct, cancer cell invasion relies on the underlying migration machinery to invade target tissues.
Cell migration requires the coordinated effort of numerous spatially-regulated signaling …
A Novel Approach For The Identification Of Cytoskeletal And Adhesion A-Kinase Anchoring Proteins, Laura Taylor Director
A Novel Approach For The Identification Of Cytoskeletal And Adhesion A-Kinase Anchoring Proteins, Laura Taylor Director
Graduate College Dissertations and Theses
A-kinase anchoring proteins (AKAPs) are signaling scaffolds which provide spatial and temporal organization of signaling pathways in discrete subcellular compartments. Through tethering the cyclic-AMP dependent protein kinase A (PKA), AKAPs target PKA activity to distinct regions in the cell, bringing PKA in close proximity to its target proteins. This provides a high level of specificity and regulation of PKA and its role in mediating a number of biological processes, one of which is cell migration. Cell migration is a highly dynamic and fundamental process, when misregulated can lead to a number of pathologies. The process of cell migration requires integration …
Direct And Indirect Targets Of Jagged1/Notch1 Signaling In Reactive Astrocytes., Matthew David Lecomte
Direct And Indirect Targets Of Jagged1/Notch1 Signaling In Reactive Astrocytes., Matthew David Lecomte
Graduate College Dissertations and Theses
Stroke or cerebral vascular accident (CVA) is the 4th leading cause of mortality and the principle cause of long-term disability in the United States. Unfortunately, current reperfusion-based treatments (e.g. thrombolysis, tPA) cannot be administered to the majority of patients presenting with ischemic stroke. Accordingly, new treatments for ischemic stroke are desperately needed.
Reactive astrocytes perform key roles in tissue repair and remodeling following stroke such as preservation and repair of the blood-brain barrier, modulation of immune cell invasion, glutamate uptake and neuroprotection, and glial scar formation. The proliferative subpopulation of reactive astrocytes found immediately adjacent to the infarct core after …
Determining The Role Of The Ergic-53 Cargo Receptor Complex In Arenavirus Propagation, Joseph P. Klaus
Determining The Role Of The Ergic-53 Cargo Receptor Complex In Arenavirus Propagation, Joseph P. Klaus
Graduate College Dissertations and Theses
Arenaviruses and hantaviruses are human pathogens that cause significant morbidity and mortality. The current lack of vaccines and treatment options for these viruses is a global concern. Despite producing only 4 proteins, these viruses are able to maintain a persistent and asymptomatic infection in wild rodents while being continuously shed into the environment. In humans, these viruses cause a spectrum of diseases ranging from aseptic meningitis to severe hemorrhagic fever syndromes. Little is known about how arenavirus and hantavirus proteins engage and interact with the human proteome during the complex process of viral biogenesis, or how the interactions with human …
The Contribution Of Purinergic P2x And P2y Receptors To The Excitability Of Mouse Vomeronasal Sensory Neurons, Jonathan Vick
The Contribution Of Purinergic P2x And P2y Receptors To The Excitability Of Mouse Vomeronasal Sensory Neurons, Jonathan Vick
Graduate College Dissertations and Theses
Olfaction, the sense of smell, allows animals to perceive the multitude of volatile and nonvolatile molecules present in the environment. In many mammals, such as mice and rats, there are four unique chemosensory organs including the (1) main olfactory epithelium (MOE), (2) septal organ, (3) Grüneberg ganglion, and (4) vomeronasal organ (VNO). While the VNO detects some general volatile odorants, it is further specialized for the detection of behaviorally relevant nonvolatile odorants or pheromones. In rodents, the VNO is encased within a bony capsule and located at the base of the nasal cavity. Odorants are detected by vomeronasal sensory neuron …
Mitochondrial Structure And Function As A Therapeutic Target In Malignant Mesothelioma, Brian Cunniff
Mitochondrial Structure And Function As A Therapeutic Target In Malignant Mesothelioma, Brian Cunniff
Graduate College Dissertations and Theses
Malignant mesothelioma (MM) is a rare tumor associated with occupational exposure to asbestos with no effective treatment regime. Evaluation of mitochondrial function in human MM cell lines revealed a common tumor phenotype: in comparison to immortalized or primary human mesothelial cells, MM tumor cells displayed a more oxidized mitochondrial environment, increased expression of mitochondrial antioxidant enzymes, and altered mitochondrial metabolism. Earlier work by our laboratory indicated that increases in mitochondrial reactive oxygen species (mROS) in MM cell lines supports expression of FOXM1, an oncogenic transcription factor that contributes to increased cell proliferation and chemoresistance. These studies sought to investigate targeting …