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Status Epilepticus Induced Alterations In Hippocampal Anatomy And Neurotransmission, Denise K. Grosenbaugh
Status Epilepticus Induced Alterations In Hippocampal Anatomy And Neurotransmission, Denise K. Grosenbaugh
Theses and Dissertations
Status epilepticus (SE) is a life-threatening neurologic emergency occurring when the brain is in an unrelenting state of seizure activity. Approximately 40% of people who encounter a single event of SE go on to develop epilepsy, characterized by spontaneously occurring seizures. While the exact mechanisms underlying seizure origin are not understood, at a fundamental level seizures initiate due to an imbalance between inhibitory and excitatory neurotransmission. We explored the impact of SE and the development of epilepsy on GABAA receptor mediated inhibitory neurotransmission and kainate receptor (KAR) mediated excitatory neurotransmission.
Stiripentol (STP), a positive allosteric modulator of the GABAA receptor, …