Medicine and Health Sciences Commons^™

Konsep Diagnosis Dan Penatalaksanaan Fraktur Osteoporosis Terkini, I Gusti Ngurah Wien Aryana, Febyan Febyan

Jurnal Penyakit Dalam Indonesia

Osteoporosis is a metabolic bone disease that is caused by a decreased amount of bone mass, and microarchitectural damage to bone tissue that affects the bone to break easily. Osteoporosis can be divided into primary and secondary etiologies. Vertebral, hip, distal radius, and proximal humerus are the most common predilection of fracture complication due to osteoporosis. The diagnosis of osteoporotic fractures is established based on the identification of risk factors, general clinical manifestations, specific manifestation from each fracture predilection, and advanced examinations, including radiology imaging and dual-energy x-ray absorptiometry. The purpose of osteoporotic fractures management in elderly is a stable …

Attitudes Toward Persons With Disabilities And Disability Awareness Of University Students Providing Healthcare, Canan Ertemoğlu Öksüz, Özlem Kanber Uzun, Şahi Nur Kalkışım, Nihat Burak Zihni

Makara Journal of Health Research

Background: This study aims to determine the attitudes and disability awareness of university students who provide health services to persons with disabilities.

Methods: This study included 291 volunteer students studying at the Vocational School of Health Services, Karadeniz Technical University (KTU), and conducting clinical practice at KTU Farabi Hospital. A sociodemographic form was used to determine the individual characteristics of the students included in this study, and the Attitudes toward Disabled Persons Scale (ATDP) was applied to determine their attitudes toward persons with disabilities.

Results: The students’ average ATDP score was 61.75 ± 12.34. Statistically significant differences …

Relation Of Salivary Alpha-Amylase (Saa) Concentration To Fatigue Biomarkers In Palm Oil Office Workers In Jambi Province: Preliminary Study, David Kusmawan, Willia Novita Eka Rini, Wahyu Indah Dewi Aurora

Makara Journal of Science

The salivary α-amylase (sAA) concentration has a potential role as a biological indicator of occupational fatigue. This study aimed to determine the levels of sAA and its influencing factors. This research used a cross-sectional design with a sample of 40 office staff respondents at PT. X (Persero). Mental workload (MWL), sleep quality, and occupational fatigue were measured using the NASA-Total Load Index (TLX), Pittsburgh Sleep Quality Index, and Industrial Fatigue Research Committee, respectively. Meanwhile, the basic sAA levels was measured through the sandwich enzyme-linked immunosorbent assay method using the Bioenzy® Kit Assay. Descriptive analysis showed that the workers were mostly …

Penyembuhan Luka: Aspek Seluler Dan Biomolekuler, Yefta Moenadjat

Department of Surgery Teaching Materials and Monographs

Mengulas aspek seluler dan molekuler penyembuhan luka di setiap fase, dimulai dari hemostasis, inflamasi dan resolusi inflamasi, proliferasi, dan maturasi. Pada bagian terakhir dulas pula gangguan proses penyembuhan luka (luka kronik, non–healing wound) yang kerap dijumpai di klinik.

Respons Inflamasi Pada Kasus Bedah, Yefta Moenadjat

Department of Surgery Teaching Materials and Monographs

Buku ini mengulas aspek seluler dan molekuler respons inflamasi pada beberapa kasus bedah, baik akut maupun kronis yang kerap dihadapkan pada masalah di klinik. Beberapa topik diulas antara lain kasus dengan respons inflamasi akut seperti trauma berat, luka bakar, cedera kepala dan respons inflamasi pada pediatrik serta beberapa kasus kronik seperti respons inflamasi pada diabetes mellitus dan lanjut usia

Effect Of Calorie Restriction On The Expression Of Sirtuin1 As An Antiaging Biomarker, Raya Makarim Penantian, Radiana Dhewayani Antarianto, Novi Silvia Hardiany

Makara Journal of Science

Calorie restriction (CR) is the most effective method for delaying aging and preventing the onset of age-related diseases. Sirtuins constitute a family of nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylases. Their activity can be regulated by NAD⁺/NADH levels, which are influenced by nutrient intake, a variable acted upon by CR. This review elaborates on the link between CR and sirtuin1 (SIRT1). It retrieved articles from several sources, such as ClinicalKey, PubMed, and ScienceDirect. It discusses the up-to-date knowledge of how SIRT1 acts as a nutrient sensor and regulator of molecular mechanisms. These mechanisms include the control of the cell …

Association Between Rs2787094 Genetic Variants In Adam33 Gene And Asthma In Indonesian Population: Preliminary Study, Kencono Viyati, Kinasih Prayuni, Yenni Zulhamidah, Intan Razari, Rika Yuliwulandari

Makara Journal of Health Research

Background: Asthma is a multifactorial disease that encompasses a multitude of genetic and environmental factors. One such factor is the disintegrin and metalloprotein-33 (ADAM33) gene, which is correlated with asthma and bronchial hyperresponsiveness. Previous studies conducted on Asian populations have reported a significant association between rs2787094 polymorphism in the ADAM33 gene and asthma.

Methods: Our study involved 153 Indonesian participants. TaqMan genotyping assay was used to analyze rs2787094 polymorphism in the ADAM33 gene.

Results: No significant association was detected between the allele and genotype frequencies of rs2787094 and asthma in the case and control subjects (p …

Sindrom Respons Inflamasi Sistemik, Yefta Moenadjat

Department of Surgery Teaching Materials and Monographs

Materi perkuliahan memuat uraian respons inflamasi pascatrauma yang berkembang menjadi sindrom respons inflamasi sistemik, berakhir dengan kegagalan organ multipel ditinjau dari aspek biomolekuler.

Buku ini merupakan bagian pertama dari seri inflamasi yang disusun dalam bentuk digital dan dipublikasi menurut konsep lisensi Commons Attribution-NonCommercial 4.0 International License untuk tujuan diseminasi.

Penggunaan Whole Body Vibration Training Pada Kasus Chronic Ankle Instability Terhadap Peningkatan Keseimbangan Pada Atlet: Studi Literatur, Aditya Denny Pratama, Muhamad Nabiel

Jurnal Vokasi Indonesia

Manusia mempunyai foot and ankle yang berfungsi sebagai permukaan utama antara tanah dan tubuh selama manusia melakukan aktivitas sehari-harinya. Hal tersebut mengharuskan foot dan ankle complex mampu menahan tumpuan tubuh, beradaptasi dengan permukaan yang tidak rata, dan sebagai penggerak yang efisien. Ankle sprain merupakan salah satu cedera di bidang muskuloskeletal yang paling sering terjadi. Cedera ankle sprain umumnya paling sering terjadi dialami oleh atlet kompetitif. Cedera ankle sprain juga memiliki tingkat kekambuhan yang tinggi. Cedera ini dapat menimbulkan masalah terkait dengan perkembangan Chronic Ankle Instability (CAI). CAI adalah suatu kondisi pengulangan cedera Ankle yang bertahan selama lebih dari 1 …

Rasio Neutrofil Limfosit Dan Kadar D-Dimer Berdasarkan Derajat Keparahan Pasien Covid-19 Di Rumah Sakit Semen Padang : Studi Kasus Kontrol, Hanifa Zahra Besri, Efrida Efrida, Yusri Dianne Jurnalis, Andani Eka Putra, Dewi Wahyu Fitrina, Husni Husni

Jurnal Penyakit Dalam Indonesia

Introduction. Coronavirus Disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) which in 2020 was declared a global pandemic. In the management of COVID-19, patients are classified according to the severity. Identifying prognostic factors at an early stage helps assess severity risks. Abnormal hematological parameters were present in COVID-19 patients such as the elevation of neutrophil lymphocyte ratio (NLR) and D-dimer patients. This study aimed to determine the NLR and D-dimer levels based on the severity of COVID-19 patients.

Methods. This study was an observational analytical study that used a case-control approach using 100 medical records of …

Peran Penting Inflamasom Nlrp3 Pada Aterosklerosis, Dewi Sukmawati

Jurnal Penyakit Dalam Indonesia

Cardiovascular diseases (CVDs) still contribute as the main cause of mortality and premature mortality worldwide. In Indonesia, CVDs contribute to 35% of the main cause of death in non-communicable diseases followed by diabetes at 6%. The ischemic heart disease and acute ischemic stroke is the main cause of death in Indonesia due to atherosclerosis. Atherosclerosis is a multifactorial cause, with chronic inflammation which causes myocardial infarction and acute ischemic stroke. Research demonstrated that one of the underlying mechanisms of atherosclerosis is inflammation. The current research suggested that inflammation could activate a complex of cytosol proteins, namely nucleotide-binding oligomerization domain-like receptor …

Comparative Evaluation Of Scar Tissue From Chest Tube Wound Closure Using Knotless And Conventional Methods Using The Patient And Observer Scar Assessment Scale, Adrian N. Tangkilisan, Mendy H. Oley, Maximillian C. Oley, Claudia Loho, Wega Sukanto, Christha Zenithy Tamburian, Fima L.F.G. Langi

The New Ropanasuri Journal of Surgery

Introduction. Chest tube placement is widely practiced; most medical doctors can do this safely. However, releasing the chest tube can be a painful and challenging experience for the patient. A novel method has been developed with a new suture material that does not need to be knotted. The Patient and Observer Scar Assessment Scale (POSAS) provides objective and subjective scar assessment. This study aimed to compare the scars associated with chest tube release between the conventional and knotless methods.

Methods. The study was a controlled trial in which patients were divided into two groups. The scar assessment was …

Interaction Between Fluoxetine And Risperidone And Its Association With Clinical Outcomes In Schizophrenic Patients, Fitri Rachmaini, Dian Ayu Juwita, Rahmad Abdillah, Rezy Dwi Afrianti, Fatma Sri Wahyuni

Pharmaceutical Sciences and Research

The concurrent use of fluoxetine and risperidone to treat schizophrenia may result in drug interactions. This study aims to analyse the clinical outcomes of fluoxetine-risperidone therapy and the possibility of their interaction in schizophrenic patients. The clinical outcomes are patient status at the time of hospital discharge, the length of hospitalisation and the Positive and Negative Syndrome Scale- Excitement Component (PANSS-EC). This study was conducted prospectively in psychiatric ward of HB Saanin Mental Hospital from May to October 2021 and study subjects were selected using consecutive sampling technique with inclusion criteria. Forty-three patients were eligible for this study. Research data …

Comparison Of Maturation Stages Of Natural Killer Cell Differentiation Culture From Cultured And Freshly Isolated Umbilical Cord Blood Hematopoietic Stem Cells, Samuel Febrian Wijaya, Retno Lestari, Inna Rahmawati, Imelda Rosalyn Sianipar, Robby Nuraditya, Iqbal Fasha, Gita Pratama, Radiana Dhewayani Antarianto

Makara Journal of Health Research

Background: Natural killer (NK) cells originate from the differentiation of hematopoietic stem cells (HSCs) in the common lymphoid progenitor pathway, and HSCs can be obtained from umbilical cord blood (UCB). Comparative studies of NK cell differentiation between cultured and freshly isolated HSCs are important in the development of NK cell therapy for cancer. This study aimed to compare the maturation stages of NK cell differentiation between cultured and newly isolated HSC samples using interleukin-2 in the absence of feeder cells.

Methods: Differentiation cultures were divided into two groups according to HSC source. Giemsa staining and flow cytometry were …

Head And Neck Tumor Histopathological Image Representation With Pre- Trained Convolutional Neural Network And Vision Transformer, Ranny Rahaningrum Herdiantoputri, Daisuke Komura, Tohru Ikeda, Shumpei Ishikawa

Journal of Dentistry Indonesia

Image representation via machine learning is an approach to quantitatively represent histopathological images of head and neck tumors for future applications of artificial intelligence-assisted pathological diagnosis systems. Objective: This study compares image representations produced by a pre-trained convolutional neural network (VGG16) to those produced by a vision transformer (ViT-L/14) in terms of the classification performance of head and neck tumors. Methods: W hole-slide images of five oral t umor categories (n = 319 cases) were analyzed. Image patches were created from manually annotated regions at 4096, 2048, and 1024 pixels and rescaled to 256 pixels. Image representations were …

Potential Of Dietary Flavonoids In The Prevention And Therapy Of Covid-19 : Focusing In Mast Cell - Calcium Ion Channel Axis, Aryo Tedjo

Indonesian Journal of Medical Chemistry and Bioinformatics

Syndrome Acute Respiratory Syndrome Corona Virus-2 (SARS COV2) is the virus that causes the COVID19 disease and has caused more than 4 million deaths worldwide. This virus infects the host cell through the interaction between the virus’s glycoprotein S molecule with the ACE2 which is the virus receptor, binding, undergoes membrane fusion and enters the cell and replicates in it. Currently, several strategies used in developing anti-viral compounds are targeting compounds that play a role in the process of entering the virus into host cells such as ACE2, S glycoprotein, and TMPRSS2, while some target main proteases such as RNA …