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Full-Text Articles in Medicine and Health Sciences
Mechanisms And Integration Of Signal Pathway: A Role For Calpains?, Dorothy E. Croall
Mechanisms And Integration Of Signal Pathway: A Role For Calpains?, Dorothy E. Croall
University of Maine Office of Research Administration: Grant Reports
In order to survive cells must sense and respond to changes in their environment. Environmental cues trigger a variety of events within cells. The concentration and movements of calcium ions are essential regulators of many of these cellular responses. Proper control of intracellular calcium is essential because at thigh levels calcium can lead to cell damage or death. Calcium accomplishes it effects through binding to specific proteins such as calmodulin and calpain. Calmodulin, named for its ability to bind calcium and to modulate the activity of other cellular components, is an important mediator of calcium signals and its mechanism of …
The Role Of Osteopontin In Vascular Remodeling, Daniel Myers
The Role Of Osteopontin In Vascular Remodeling, Daniel Myers
Electronic Theses and Dissertations
Chronic obstructive vascular disease is a major contributor to mortality in developed nations. The pathology typically involves neointima formation accompanied by vascular remodeling in the presence of inflammation. The disease can be modeled in animals with the response to a direct injury of the vasculature. This text describes a project examining the role of osteopontin (OPN) in vascular remodeling. The projectis goal was to mechanistically describe the contribution of OPN to the vascular injury response. The hypothesis that the presence of OPN affects the formation of neointima and constrictive remodeling associated with vascular injury was addressed using the strategy of …