Medicine and Health Sciences Commons^™

Evidence For A Non-Genomic Action Of Testosterone In Skeletal Muscle Which May Improve Athletic Performance: Implications For The Female Athlete, J R Dent, D K Fletcher, Michael Mcguigan

Research outputs 2012

This review will focus on the proposed second mode of testosterone action (now termed non-genomic) that appears to occur independently of the traditional transcriptional mechanism in mammalian skeletal muscle cells which may enhance skeletal muscle contractile properties. This mechanism of testosterone action differs from the traditional pathway, originating at the cell membrane, having a rapid onset of action, requiring second messengers to execute its effects and is insensitive to inhibitors of traditional androgen receptor action, transcription and protein synthesis. Importantly, unlike the traditional action of testosterone in skeletal muscle, this non-genomic pathway is shown to have a direct acute effect …