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Medicine and Health Sciences Commons

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Medical Sciences

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Selected Works

2013

Endocultivation

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Full-Text Articles in Medicine and Health Sciences

The Primordium Of A Biological Joint Replacement: Coupling Of Two Stem Cell Pathways In Biphasic Ultrasound Compressed Gel Niches, Mariea Brady, Sureshan Sivananthan, Vivek Mudera, Qin Liu, Joerg Wiltfang, Patrick Warnke Dec 2013

The Primordium Of A Biological Joint Replacement: Coupling Of Two Stem Cell Pathways In Biphasic Ultrasound Compressed Gel Niches, Mariea Brady, Sureshan Sivananthan, Vivek Mudera, Qin Liu, Joerg Wiltfang, Patrick Warnke

Qin Liu

The impaired temporomandibular joint might be the first to benefit from applied tissue engineering techniques because it is small and tissue growth in larger amounts is challenging. Bone and cartilage require different competing environmental conditions to be cultivated in vitro. But coupling both the osteogenic and cartilaginous pathways of mesenchymal stem cell differentiation in homeostasis will be a key essential to grow osteochondral constructs or even the first biological joint replacement in the future.

The aim of this study was to test a single source biomaterial and a single source cell type to engineer a biphasic osteochondral construct in vitro …