Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health Sciences
Ayx1 Dna-Decoy Compound Prevents The Maintenance Of Pain After Incisional, Inflammatory Or Neuropathic Injury, Julien Mamet, Michael Klukinov, Shelle A. Malkmus, Renee R. Donahue, Samantha Williams, Bradley K. Taylor
Ayx1 Dna-Decoy Compound Prevents The Maintenance Of Pain After Incisional, Inflammatory Or Neuropathic Injury, Julien Mamet, Michael Klukinov, Shelle A. Malkmus, Renee R. Donahue, Samantha Williams, Bradley K. Taylor
Renee R. Donahue
The persistence of pain following surgery or trauma limits recovery, physical rehabilitation and the return to a normal quality of life. AYX1 is a compound developed for preventing the maintenance of post-surgical pain with a single intrathecal administration prior to surgery. Post-surgical pain arises from a combination of mechanical/incisional, inflammatory and often nerve trauma. Early in the development of pain following such injury, there are waves of gene regulation in DRG and spinal cord neurons leading to long-term sensitization and the maintenance of pain over time. These transcriptional events are necessary to the development and maintenance of pain and involve …