Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health Sciences
The Hippo/Yap Pathway Interacts With Egfr Signaling And Hpv Oncoproteins To Regulate Cervical Cancer Progression, Chunbo He, Dagan Mao, Guohua Hua, Xiangmin Lv, Xingcheng Chen, Peter C. Angeletti, Jixin Dong, Steven W. Remmenga, Kerry J. Rodabaugh, Jin Zhou, Paul F. Lambert, Peixin Yang, John S. Davis, Cheng Wang
The Hippo/Yap Pathway Interacts With Egfr Signaling And Hpv Oncoproteins To Regulate Cervical Cancer Progression, Chunbo He, Dagan Mao, Guohua Hua, Xiangmin Lv, Xingcheng Chen, Peter C. Angeletti, Jixin Dong, Steven W. Remmenga, Kerry J. Rodabaugh, Jin Zhou, Paul F. Lambert, Peixin Yang, John S. Davis, Cheng Wang
Nebraska Center for Virology: Faculty Publications
The Hippo signaling pathway controls organ size and tumorigenesis
through a kinase cascade that inactivates Yes-associated
protein (YAP). Here, we show that YAP plays a central role in
controlling the progression of cervical cancer. Our results suggest
that YAP expression is associated with a poor prognosis for cervical
cancer. TGF-α and amphiregulin (AREG), via EGFR, inhibit the Hippo
signaling pathway and activate YAP to induce cervical cancer cell
proliferation and migration. Activated YAP allows for up-regulation
of TGF-α, AREG, and EGFR, forming a positive signaling loop to
drive cervical cancer cell proliferation. HPV E6 protein, a major
etiological molecule of …