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Full-Text Articles in Medicine and Health Sciences
Hif1a-Dependent Induction Of Alveolar Epithelial Pfkfb3 Dampens Acute Lung Injury, Christine U Vohwinkel, Nana Burns, Ethan Coit, Xiaoyi Yuan, Eszter K Vladar, Christina Sul, Eric P Schmidt, Peter Carmeliet, Kurt Stenmark, Eva S Nozik, Rubin M Tuder, Holger K Eltzschig
Hif1a-Dependent Induction Of Alveolar Epithelial Pfkfb3 Dampens Acute Lung Injury, Christine U Vohwinkel, Nana Burns, Ethan Coit, Xiaoyi Yuan, Eszter K Vladar, Christina Sul, Eric P Schmidt, Peter Carmeliet, Kurt Stenmark, Eva S Nozik, Rubin M Tuder, Holger K Eltzschig
Journal Articles
Acute lung injury (ALI) is a severe form of lung inflammation causing acute respiratory distress syndrome in patients. ALI pathogenesis is closely linked to uncontrolled alveolar inflammation. We hypothesize that specific enzymes of the glycolytic pathway could function as key regulators of alveolar inflammation. Therefore, we screened isolated alveolar epithelia from mice exposed to ALI induced by injurious ventilation to assess their metabolic responses. These studies pointed us toward a selective role for isoform 3 of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3). Pharmacologic inhibition or genetic deletion of Pfkfb3 in alveolar epithelia (Pfkfb3loxP/loxP SPC-ER-Cre+ mice) was associated with profound increases in ALI during …
Ccl4 Regulates Eosinophil Activation In Eosinophilic Airway Inflammation, Hanh Hong Chu, Yoshiki Kobayashi, Dan Van Bui, Yasutaka Yun, Linh Manh Nguyen, Akitoshi Mitani, Kensuke Suzuki, Mikiya Asako, Akira Kanda, Hiroshi Iwai
Ccl4 Regulates Eosinophil Activation In Eosinophilic Airway Inflammation, Hanh Hong Chu, Yoshiki Kobayashi, Dan Van Bui, Yasutaka Yun, Linh Manh Nguyen, Akitoshi Mitani, Kensuke Suzuki, Mikiya Asako, Akira Kanda, Hiroshi Iwai
Journal Articles
Eosinophilic chronic rhinosinusitis (ECRS) is a refractory airway disease accompanied by eosinophilic inflammation, the mechanisms of which are unknown. We recently found that CCL4/MIP-1β-a specific ligand for CCR5 receptors-was implicated in eosinophil recruitment into the inflammatory site and was substantially released from activated eosinophils. Moreover, it was found in nasal polyps from patients with ECRS, primarily in epithelial cells. In the present study, the role of epithelial cell-derived CCL4 in eosinophil activation was investigated. First, CCL4 expression in nasal polyps from patients with ECRS as well as its role of CCL4 in eosinophilic airway inflammation were investigated in an in …
Editorial: The Role Of Hmgb1 In Immunity, M. Son, B. Diamond, J. Shin
Editorial: The Role Of Hmgb1 In Immunity, M. Son, B. Diamond, J. Shin
Journal Articles
No abstract provided.
Forebrain Cholinergic Signaling Regulates Innate Immune Responses And Inflammation, K. R. Lehner, H. A. Silverman, M. E. Adorissio, A. Roy, A. Al-Onaizi, S. S. Chavan, Y. Al-Abed, C. N. Metz, K. J. Tracey, V. A. Paviov, +6 Additional Authors
Forebrain Cholinergic Signaling Regulates Innate Immune Responses And Inflammation, K. R. Lehner, H. A. Silverman, M. E. Adorissio, A. Roy, A. Al-Onaizi, S. S. Chavan, Y. Al-Abed, C. N. Metz, K. J. Tracey, V. A. Paviov, +6 Additional Authors
Journal Articles
No abstract provided.
Immunization Elicits Antigen-Specific Antibody Sequestration In Dorsal Root Ganglia Sensory Neurons, M. Gunasekaran, P. K. Chatterjee, A. Shih, G. H. Imperato, G. Kumar, A. Lee, C. Bouton, B. Sherry, B. Diamond, T. R. Coleman, C. N. Metz, K. J. Tracey, S. S. Chavan, +9 Additional Authors
Immunization Elicits Antigen-Specific Antibody Sequestration In Dorsal Root Ganglia Sensory Neurons, M. Gunasekaran, P. K. Chatterjee, A. Shih, G. H. Imperato, G. Kumar, A. Lee, C. Bouton, B. Sherry, B. Diamond, T. R. Coleman, C. N. Metz, K. J. Tracey, S. S. Chavan, +9 Additional Authors
Journal Articles
No abstract provided.
Editorial: Neuro-Immune Interactions In Inflammation And Autoimmunity, N. Terrando, V. A. Pavlov
Editorial: Neuro-Immune Interactions In Inflammation And Autoimmunity, N. Terrando, V. A. Pavlov
Journal Articles
No abstract provided.
Molecular And Functional Neuroscience In Immunity, V. A. Pavlov, S. S. Chavan, K. J. Tracey
Molecular And Functional Neuroscience In Immunity, V. A. Pavlov, S. S. Chavan, K. J. Tracey
Journal Articles
No abstract provided.
Altered Leukocyte Gene Expression After Traumatic Spinal Cord Injury: Clinical Implications, P. E. Herman, O. Bloom
Altered Leukocyte Gene Expression After Traumatic Spinal Cord Injury: Clinical Implications, P. E. Herman, O. Bloom
Journal Articles
No abstract provided.
Persons With Chronic Spinal Cord Injury Have Decreased Natural Killer Cell And Increased Toll-Like Receptor/Inflammatory Gene Expression, P. Herman, A. Stein, K. Gibbs, I. Korsunsky, P. Gregersen, O. Bloom
Persons With Chronic Spinal Cord Injury Have Decreased Natural Killer Cell And Increased Toll-Like Receptor/Inflammatory Gene Expression, P. Herman, A. Stein, K. Gibbs, I. Korsunsky, P. Gregersen, O. Bloom
Journal Articles
No abstract provided.