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Full-Text Articles in Medicine and Health Sciences
Dietary Nitrate Acutely And Markedly Increased Exhaled Nitric Oxide In A Cystic Fibrosis Case, Conor Kerley, Emma Kilbride, Peter Greally, Basil Elnazir
Dietary Nitrate Acutely And Markedly Increased Exhaled Nitric Oxide In A Cystic Fibrosis Case, Conor Kerley, Emma Kilbride, Peter Greally, Basil Elnazir
Articles
Airway nitric oxide (NO) is a ubiquitous signaling molecule with bronchoprotective, antiinflammatory and anti-infective roles. Cystic fibrosis (CF) is a chronic lung condition associated with deceased exhaled NO. Strategies to increase exhaled NO in CF have yielded inconsistent results. A potential new method of increasing systemic NO involves ingestion of dietary, inorganic nitrate which is reduced to nitrite and NO. We present the case of a 12 year-old, athletic male with CF who demonstrated acute but marked increases in exhaled NO following dietary nitrate consumption compared to placebo.
Dietary Nitrate Increases Exercise Tolerance In Patients With Non-Ischemic, Dilated Cardiomyopathy-A Double-Blind, Randomized, Placebo-Controlled, Crossover Trial., Conor Kerley, James O'Neill, Venu Reddy Bijjam, Ciara Blaine, Philip James, Liam Cormican
Dietary Nitrate Increases Exercise Tolerance In Patients With Non-Ischemic, Dilated Cardiomyopathy-A Double-Blind, Randomized, Placebo-Controlled, Crossover Trial., Conor Kerley, James O'Neill, Venu Reddy Bijjam, Ciara Blaine, Philip James, Liam Cormican
Articles
No abstract provided.
Dietary Nitrate In Decreased Blood Pressure In Obstructive Sleep Apnoea Syndrome: A Series Of N-Of-1trials, Conor Kerley, Liam Cormican, Eamon Dolan
Dietary Nitrate In Decreased Blood Pressure In Obstructive Sleep Apnoea Syndrome: A Series Of N-Of-1trials, Conor Kerley, Liam Cormican, Eamon Dolan
Articles
Obstructive sleep apnoea syndrome (OSAS) is a consequence of repetitive oropharyngeal airway narrowing/closure during sleep resulting in chronic intermittent hypoxaemia [1]. OSAS is regarded as an independent risk factor for hypertension (HTN) development [2] and is associated with decreased cerebral blood flow [3], leading to daytime neuropsychological sequelae [1]. Blood pressure (BP) follows a circadian rhythm termed dipping and the absence of nocturnal BP dipping is associated with target-organ damage, cerebrovascular disease, myocardial remodelling and increased cardiovascular events/mortality [4]. Abnormal BP in OSAS typically manifests as reduced nocturnal BP dipping [5]. Although continuous positive airway pressure therapy (CPAP) represents the …