Medicine and Health Sciences Commons^™

Impact Of Metformin On Feeding, Behavior, And Metabolism In Drosophila Melanogaster., Erica E. Hassoun, Heba Kourhabi, Jason Bui Ho, Dae-Sung Hwangbo

Undergraduate Research Events

Metformin is a first-line drug used in the treatment of type II diabetes mellitus and is the 4th-most prescribed drug in the United States. It functions in lowering blood glucose levels and increasing insulin sensitivity. Despite its wide scale use, the degree to which it affects aspects of behavior and metabolism unrelated to diabetes is not fully understood.

Recent studies have attempted to fill this gap, particularly in the context of metformin’s impact on lifespan. We decided to extend this research by focusing on measurable behaviors as well as traits related to metabolism and physiology. Using the fruit fly Drosophila …

Identifying Barriers To Statin Therapy In Diabetic Patients In A Large Ambulatory Practice, Jennifer Moyer, Md, Rachel Ehrman-Dupre, Md, Andrew Rabovsky, Md, Simon Newsom, Md, Pooja Padgaonkar, Md, Julita Mitchell, Md, Sarah Hirsh, Md, Madeline Taskier, Md, Robert Wiley, Md, Lilli Flink, Md, Greta Bires, Md, Geoffrey Mills, Md

House Staff Quality Improvement and Patient Safety Conference (2020-)

Aim 1: To understand the root cause(s) for gaps in statin therapy within a large ambulatory care practice.

Aim 2: To improve provider awareness of indications for statin therapy, as recommended by the ACC/AHA guidelines.

Aim 3: To increase the proportion of patients with diabetes at our practice that are on statin therapy.

Continuous Glucose Monitors To Decrease Hypoglycemia, Sara B. Woodcock

MSN Capstone Projects

Diabetes is a disease that affects millions of people from children to older adults. There is no cure, although it can be managed to prevent complications. Education of student nurses is where they are born and raised to become nurses who save and change lives. Teaching student nurses in depth about diabetes as a disease and the treatments that best fit their specific needs is where educating patients begins. Learning about a secondary option for blood glucose checks can make all the difference for several patients. Multiple finger sticks daily has been the leading way to check blood sugar for …

Detection Of P2x3 In Drg Using An Automated Approach To Immunoblotting, Jess, Junghoon Lee, Audrey J. Stone, Michelle L. Harrison

International Journal of Exercise Science: Conference Proceedings

Exaggerated cardiovascular (CV) responses to exercise can lead to adverse CV events. Previous studies have reported that P2X₃ receptors, found on the peripheral endings of afferents, contribute to an exaggerated exercise pressor reflex in individuals with CV-related diseases. One way to investigate the role played by these receptors in CV pathophysiology is through immunoblotting. The Jess (Protein Simple) provides an automated option for the protein separation and immunoblotting of the traditional Western Blot and allows for total protein staining, an improvement over the use of loading controls to normalize for sample loading variability. PURPOSE: The purpose of this study …

The Effect Of Acute And Chronic Thermotherapy On Type 2 Diabetic Skeletal Muscle Cell Viability And Gene Expression: Pilot Study, Louay Bachnak, Jean Sparks, Xavier F. Gonzales, Daniel Newmire, Felix Omoruyi

International Journal of Exercise Science: Conference Proceedings

Diabetes is a chronic metabolic disease affecting millions of people globally. Type 2 diabetes is associated with insulin resistance or a defective secretion of insulin from the pancreas. The skeletal muscle system accounts for 80% of glucose uptake and is a vital player in healthy aging and muscle mass maintenance. PURPOSE: The purpose of this study was to investigate the effects of thermotherapy on gene expression and cell viability in Type 2 Diabetic skeletal muscle. METHODS: Human skeletal muscle myoblast (HSMM) and Diabetic Type 2 human skeletal muscle myoblast (D-HSMM) (Lonza Inc, Walkersville, MD) were cultured until 90% confluency was, …

Plasma Lipid, Glucose, And Immune Responses To Consumption Of Nutritive And Nonnutritive Sweeteners And Exercise, Jarrett Walbolt, Yunsuk Koh

International Journal of Exercise Science: Conference Proceedings

Although nonnutritive sweeteners are widely used as substitutes for nutritive sweeteners, it is currently uncertain how these commonly available sweeteners affect plasma glucose and lipid metabolism. PURPOSE: To examine how nutritive and nonnutritive sweeteners influence plasma lipid profiles, complete blood counts, and plasma glucose content at rest and during exercise. METHODS: This randomized, double-blinded, cross-over design study included 9 healthy, college aged, individuals (4 females and 5 males). In four separate visits, participants consumed 8 oz of sweetened drink in random order with either 445mg of stevia, 507mg of aspartame, 169mg of sucralose, or 110,000mg of sucrose mixed into water. …

Evaluating Knowledge And Educating Patients About Diabetic Retinopathy Screening In Washington County, Vt, Delaney Curran

Family Medicine Clerkship Student Projects

No abstract provided.

Type 2 Diabetes Medication Breakdown, Kristen Keene

Family Medicine Clerkship Student Projects

There are many new medications for treatment of type 2 diabetes and these medications have many positive effects that go beyond lowering blood glucose. However, many of these medications are expensive and some insurance plans don’t cover them. Many patients struggle to pay for their diabetes medications and providers often are unsure of which medications will be covered by insurance. This project was designed to enhance patient education regarding diabetes medications and potential costs associated.

Evaluating Knowledge And Educating Patients About Diabetic Retinopathy Screening In Washington County, Vt, Delaney Curran

Family Medicine Clerkship Student Projects

Diabetic retinopathy (DR) is a leading cause of blindness in adults. Early detection and subsequent treatment of DR has been shown to be effective at saving vision and medical costs. However, adherence to annual dilated eye exams is relatively poor among people with diabetes. This project in Waterbury, VT aimed to identify patients' potential knowledge gaps about the connection between diabetes and eye disease, educate patients about DR with a 2 min educational video in the primary care office, and then assess their level of interest in getting an eye exam after watching the video.

Type 2 Diabetes Medication Breakdown, Kristen Keene

Family Medicine Clerkship Student Projects

There are many new medications for treatment of type 2 diabetes and these medications have many positive effects that go beyond lowering blood glucose. However, many of these medications are expensive and some insurance plans don’t cover them. Many patients struggle to pay for their diabetes medications and providers often are unsure of which medications will be covered by insurance. This project was designed to enhance patient education regarding diabetes medications and potential costs associated.

Addressing Exercise Accessibility In Winter Conditions In Milton, Vermont, Liam Du Preez

Family Medicine Clerkship Student Projects

Exercise is a critical aspect of health maintenance, especially in the context of chronic medical problems such as diabetes, heart disease, and obesity. Weather and climate conditions in Vermont directly impact Vermonters' ability to exercise, and this results in negative impacts in their health maintenance and healthcare costs nationally and locally. This project explores the direct and indirect impact of decreased exercise and explore a modality for informing patients on how to stay active safely in the winter.

Barriers To Exercise: Patients With Diabetes In Washington County, Joshua Bruce Taylor

Family Medicine Clerkship Student Projects

According to the Vermont Department of Health physical inactivity is one of the three main behaviors that predisposes patients to cancer, heart disease/stroke, lung disease, and type 2 diabetes, which result in over 50 percent of deaths among Vermonters. Washington County has a higher rate of overweight adults than the statewide average, making exercise an important component to healthier living. Barriers to exercise, especially among patients with diabetes, impose serious health ramifications for the residents of Washington County, and avenues must be made available to circumvent these barriers.

Emphasizing Year-Round Physical Activity Of Seniors In Vergennes, Vermont, Carley R. Mulligan

Family Medicine Clerkship Student Projects

Many senior citizens in the Vergennes community are active in the spring, summer, and fall with various activities, community groups, and walking. However, in the winter with colder temperatures and less sunlight, these activities are difficult to maintain, even more exacerbated by the current Covid-19 pandemic. Encouraging maintenance of physical activity throughout the winter months in Vermont is difficult, but can provide many benefits to these individuals both physically and mentally.

Increasing Awareness Of Added Sugar In The Outpatient Setting, Lauren Bougioukas

Family Medicine Clerkship Student Projects

An estimated 80% of Americans consume more than the recommended daily amount of added sugar. Added sugar consumption significantly increases risk for cardiovascular disease mortality, and is associated with body weight, type 2 diabetes, and metabolic syndrome. In the United States, added sugar consumption contributes to public health costs related to cardiovascular disease ($555 billion spent in 2016) and diabetes ($245 billion spent in 2012). Particularly in New York, nearly 40% of all New York deaths in 2014 could be attributed to cardiovascular disease and 10.5% of New York adults had diabetes in 2017. In addition to added sugar overconsumption, …