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Full-Text Articles in Medicine and Health Sciences

Chromatin Pattern Quantification For The Differentiation Of White Blood Cells, Paul Young, Ryan Cordner, Abigail Gordhamer Feb 2024

Chromatin Pattern Quantification For The Differentiation Of White Blood Cells, Paul Young, Ryan Cordner, Abigail Gordhamer

Annual Research Symposium

Nuclear chromatin patterns have been used historically to distinguish between different developmental stages and lineages of white blood cells. While it is common to characterize cells based on arbitrary ‘open’ or ‘closed’ chromatin patterns, quantification of chromatin data is lacking. By extracting nuclei from a database of white blood cells and running fractal analyses using TWOMBLI, we were able to produce meaningful data quantifying chromatin patterns. Our data were put through a random forest algorithm which grouped each point based on relationship probability. The algorithm compared immature and mature cell types as well as cells of similar maturity and differing …


Examining The Efficacy Of Treatments For Complex Regional Pain Syndrome, Michael Podcasy Jan 2024

Examining The Efficacy Of Treatments For Complex Regional Pain Syndrome, Michael Podcasy

Capstone Showcase

Complex Regional Pain Syndrome (CRPS) is a disease that affects the sensory, motor, sudomotor, vasomotor and trophic systems of patients. The pathophysiology is currently unknown and the diagnostic criteria that is used, the Budapest criteria, has its own shortcomings. This had led to hurdles in the research of the disease and well as a lack of high-quality studies on the efficacy of the many treatments currently being used to treat CRPS today. This poster explores those concepts.


Cme: Pcos Diagnostic Criteria, Lindsay R. Phillips Jan 2024

Cme: Pcos Diagnostic Criteria, Lindsay R. Phillips

Capstone Showcase

Polycystic Ovarian Syndrome, or PCOS, is a hormonal imbalance that can affect females of reproductive ages and is described as women having high androgen levels, irregular menstrual cycles, and small cysts on one or both ovaries. PCOS is difficult to accurately diagnose since the diagnostic criteria are vague and the disease falls on a wide spectrum of symptoms, leaving women underdiagnosed. Previous research has shown marked improvement in the diagnostic criteria for PCOS over the years. However, due to the vagueness in symptoms, most of the criteria has been created through expert opinion based on subjective data vs objective data. …


Herniated Nucleus Pulposus Radiculopathy In Athletes, Elizabeth G. Massel Jan 2024

Herniated Nucleus Pulposus Radiculopathy In Athletes, Elizabeth G. Massel

Capstone Showcase

Herniated nucleus pulposus (HNP), commonly referred to as intervertebral disc (IVD) herniation, is the second most common cause of neck and back pain, and most common cause of radiculopathy. The purpose of this CME article is to provide guidance on the medical management and secondary prevention of HNP in athletic populations, and highlight the pathophysiological process of mechanical overload putting athletes at a proportionately higher risk of the disease. It will address the unique pathophysiology of overuse-related HNP, as opposed to underuse, with the mechanical overload on vertebral discs associated with many sports. It will also review, with more emphasis …