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Differential Regulation Of Iress In The Aurora A Mrna By Bfgf Through The Mtor Complex Torc2 Modulates Aurora A Kinase Expression, Roy L. Voice Iii
Differential Regulation Of Iress In The Aurora A Mrna By Bfgf Through The Mtor Complex Torc2 Modulates Aurora A Kinase Expression, Roy L. Voice Iii
Dissertations & Theses (Open Access)
Identifying the mechanisms that contribute to tumorigenesis is a major area of focus in our fight against cancer. Epithelial malignant tumors, such as breast, colon, ovarian and pancreatic cancers have been shown to overexpress proteins that control cell mitosis, growth, and proliferation. One of those proteins is the Aurora A kinase. Aurora A kinase is a member of a small family of kinases that contribute to mitotic events such as centrosome duplication, separation, and maturation. Aurora A overexpression leads to genomic instability, which can contribute to tumorigenesis, on the other hand, inhibiting Aurora A expression leads to apoptosis, making it …