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Adiabatic Approximation of Johnson and Wilson Model; Blood flow; Blood volume; Brain tumor; Dynamic perfusion CT; Permeability-surface area product
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Full-Text Articles in Medicine and Health Sciences
Dynamic Perfusion Ct In Brain Tumors., Timothy Pok Chi Yeung, Glenn Bauman, Slav Yartsev, Enrico Fainardi, David Macdonald, Ting-Yim Lee
Dynamic Perfusion Ct In Brain Tumors., Timothy Pok Chi Yeung, Glenn Bauman, Slav Yartsev, Enrico Fainardi, David Macdonald, Ting-Yim Lee
Medical Biophysics Publications
Dynamic perfusion CT (PCT) is an imaging technique for assessing the vascular supply and hemodynamics of brain tumors by measuring blood flow, blood volume, and permeability-surface area product. These PCT parameters provide information complementary to histopathologic assessments and have been used for grading brain tumors, distinguishing high-grade gliomas from other brain lesions, differentiating true progression from post-treatment effects, and predicting prognosis after treatments. In this review, the basic principles of PCT are described, and applications of PCT of brain tumors are discussed. The advantages and current challenges, along with possible solutions, of PCT are presented.