Open Access. Powered by Scholars. Published by Universities.®
- Institution
- Publication
Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Prevalence, Incidence, And Persistence Of Major Depressive Symptoms In The Cardiovascular Health Study, Stephen M. Thielke Md, Ms, Paula Diehr Phd
Prevalence, Incidence, And Persistence Of Major Depressive Symptoms In The Cardiovascular Health Study, Stephen M. Thielke Md, Ms, Paula Diehr Phd
Paula Diehr
PURPOSE: To explore the association of major depressive symptoms with advancing age, sex, and self-rated health among older adults. DESIGN AND METHODS: We analyzed 10 years of annual assessments in a longitudinal cohort of 5888 Medicare recipients in the Cardiovascular Health Study. Self-rated health was assessed with a single question, and subjects categorized as healthy or sick. Major depressive symptoms were assessed using the Center for Epidemiologic Studies Short Depression Scale, with subjects categorized as nondepressed (score < 10) or depressed (> or =10). Age-, sex-, and health-specific prevalence of depression and the probabilities of transition between depressed and nondepressed states were estimated. RESULTS: The …
On The Statistical Accuracy Of Biomarker Assays Of Hiv Incidence, Ron Brookmeyer
On The Statistical Accuracy Of Biomarker Assays Of Hiv Incidence, Ron Brookmeyer
Ron Brookmeyer
Objective: To evaluate the statistical accuracy of estimates of current HIV incidence rates from cross-sectional surveys, and to identify characteristics of assays that improve accuracy.
Methods: Performed mathematical and statistical analysis of the cross-sectional estimator of HIV incidence to evaluate bias and variance. Developed probability models to evaluate impact of long tails of the window period distribution on accuracy.
Results: The standard cross-sectional estimate of HIV incidence rate is estimating a time-lagged incidence where the lag time, called the shadow, depends on the mean and the coefficient of variation of window periods. Equations show how the shadow increases with the …