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The Effects Of Rhamm On Cell Division, Cell Motility, And Tumorigenesis, Sallie Elhayek
The Effects Of Rhamm On Cell Division, Cell Motility, And Tumorigenesis, Sallie Elhayek
Electronic Thesis and Dissertation Repository
Overexpression of a RHAMM isoform (RHAMMΔ163) transforms fibroblasts but the mechanisms underlying this oncogenic function are not well understood. RHAMMΔ163 binds to the mitotic spindle and centrosomes via a C-terminal leucine zipper; these interactions are predicted to regulate genomic stability and cell polarity and proposed to account for the oncogenic function of RHAMMΔ163. We hypothesized that RHAMM leucine zipper maintains mitotic spindle integrity and impacts directional cell migration through its interactions with microtubule and centrosome structures. The consequences of a mutated leucine zipper on cell division, cell motility, and tumorigenesis were assessed. Although mutant RHAMM …