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- Keyword
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- Chronic Inflammation; Leukocytes; Enzyme Myeloperoxidase; Reactive Oxygen Species; Tyrosine Phenol Ring (1)
- Immune cells; Monocytes; Linker Histone Proteins; Chronic Adipose Tissue Inflammation; (1)
- Pancreatic Cancer; Cancer Therapy Resistance; Tumor Microenvironment; Intracellular Adaptations; Resistance-linked Genes (1)
- Pancreatic Cancer; Metastatic Pancreatic Cancer; Tumor Exosomes; Antimetabolite Agents; Chemoresistance (1)
- Preconditioning; Endogenous Protective Mechanisms; Surgical Brain Injury Rodent Model; Endogenous Fibrinogen; Perioperative Hemorrhage; Postoperative Brain Edema (1)
Articles 1 - 5 of 5
Full-Text Articles in Medicine and Health Sciences
Palmitic Acid Activation Of Dendritic Cells: Implications For Type 2 Diabetes, Dequina Angelina Nicholas
Palmitic Acid Activation Of Dendritic Cells: Implications For Type 2 Diabetes, Dequina Angelina Nicholas
Loma Linda University Electronic Theses, Dissertations & Projects
Infiltration of immune cells into visceral adipose tissue is observed in type 2 diabetes development. Monocytes are recruited to obese visceral adipose tissue in large numbers and retain the ability to differentiate into dendritic cells, important antigen presenting cells in the immune system. Differentiation of monocytes into dendritic cells likely accounts for the increased number of dendritic cells observed in the adipose tissue of type 2 diabetic patients. We have demonstrated this differentiation process is regulated in part by a major reduction of linker histone proteins. In adipose tissue, dendritic cells are exposed to high levels of saturated fatty acids. …
Curcumin: A Multi-Dimensional Approach To Pancreatic Cancer Targeting Cell Death And Exosomes, Carlos J. Diaz Osterman
Curcumin: A Multi-Dimensional Approach To Pancreatic Cancer Targeting Cell Death And Exosomes, Carlos J. Diaz Osterman
Loma Linda University Electronic Theses, Dissertations & Projects
Pancreatic cancer is currently one of the most difficult diseases to treat due to difficulty of detection and the aggressive nature of the disease. In addition, pancreatic cancer has the highest mortality rates compared to other cancer types. These mortality rates are attributable in part to increasing resistance to cancer therapy. Cancer therapy resistance is caused by adaptations that favor survival within cancer cells and their environment, termed the tumor microenvironment. Intracellular adaptations include the overexpression of resistance-linked genes, such as the inhibitor of apoptosis (IAP) family of proteins and overall resistance to cell death. Adaptations in the tumor microenvironment …
Chlorinated Tyrosine Species As Markers Of Inflammation: A Kinetic Study, Matthew Peter Curtis
Chlorinated Tyrosine Species As Markers Of Inflammation: A Kinetic Study, Matthew Peter Curtis
Loma Linda University Electronic Theses, Dissertations & Projects
Chronic inflammation is associated with numerous human diseases. During inflammation, leukocytes release the enzyme myeloperoxidase (MPO) which generates reactive oxygen species such as hypochlorous acid (HOCl). Additionally, MPO generates reactive nitrogen species. These reactive species can damage host fats, proteins, and DNA, contributing to disease pathology. Because of the reactivity and short half-lives of reactive species, measurement of surrogate markers is necessary to determine their extent and source. Chlorination of the tyrosine phenol ring by HOCl to produce 3-chlorotyrosine (3ClTyr) or nitration of the phenol ring by reactive nitrogen species to produce 3-nitrotyrosine (NO2Tyr) are two such markers. Both are …
Crotalus Snake Venom Preconditioning To Prevent Surgical Brain Injury, Cherine Hee-Sun Kim
Crotalus Snake Venom Preconditioning To Prevent Surgical Brain Injury, Cherine Hee-Sun Kim
Loma Linda University Electronic Theses, Dissertations & Projects
Preventive measures are increasingly relevant to medical practice. Preconditioning, a preemptive therapy that administers mildly harmful stimuli to induce endogenous protective mechanisms before major injury, has been shown to minimize injury in many animal models. Given the elective nature of most neurosurgical procedures, the surgical brain injury (SBI) rodent model provides an ideal platform for preconditioning. Our work shows that preconditioning with Crotalus rattlesnake venom, known for its hemorrhagic and inflammatory effects, mitigates some harmful effects of SBI. We have identified two proteins of interest in Crotalus venom: snake venom metalloproteinase (SVMP), an enzyme with hemorrhagic effects, and phospholipase A2 …
Existence Of Inhibitor Of Apoptosis In Tumor Exosomes, Malyn May Asuncion Valenzuela
Existence Of Inhibitor Of Apoptosis In Tumor Exosomes, Malyn May Asuncion Valenzuela
Loma Linda University Electronic Theses, Dissertations & Projects
Pancreatic cancer is a deadly and aggressive disease. The only option for metastatic pancreatic cancer is chemotherapy where only the antimetabolites gemcitabine (Gem) and 5-fluorouracil (5FU) are used clinically. However, resistance to these antimetabolites remains a problem highlighting the need to discover and develop new antimetabolites that will improve a patient’s overall survival. Cancer is a disease that has acquired numerous molecular, biochemical and cellular changes. Resistance to apoptosis is one of the characteristics of cancer, of which the inhibitor of apoptosis (IAP) family of proteins plays an important role. It has also been shown that cancer cells secrete vesicles …