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- Phototransduction (4)
- Diffusion (2)
- Finite volume scheme (2)
- Parabolic system (2)
- Parallel computation (2)
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- Signaling (2)
- Dark adapted rods (1)
- HIF-1α (1)
- High altitude (1)
- Hydrodynamic model (1)
- Hypoxia (1)
- Hypoxia inducible factor (1)
- Inflammation (1)
- Kinetics (1)
- Laser ablation (1)
- Light activation (1)
- Multiphase (1)
- Nanosecond laser ablation (1)
- Ode integration (1)
- Peer methods (1)
- Plasma (1)
- Rod photoreceptors (1)
- Single-photon responses (1)
- Time-stepper (1)
- Vertebrates (1)
- Publication Type
Articles 1 - 7 of 7
Full-Text Articles in Medicine and Health Sciences
Hif-1 Activation And Inflammatory Responses To Hypoxia, Shazreen Shaharuddin, Nik Mohd Afizan Nik Abd Rahman, Mas Jaffri Masarudin, Mohammedarfat N Alamassi
Hif-1 Activation And Inflammatory Responses To Hypoxia, Shazreen Shaharuddin, Nik Mohd Afizan Nik Abd Rahman, Mas Jaffri Masarudin, Mohammedarfat N Alamassi
International Journal of Aviation, Aeronautics, and Aerospace
Acute hypoxia is a significant physiological danger during high-altitude flying and military aircraft missions. The human brain requires a constant supply of oxygen to function properly, and is susceptible to settings with low availability of air oxygen. Hypoxia can influence inflammatory signalling, and both central and systemic responses can activate HIF pathway genes. HIFs are critical molecules that regulate inflammation andhypoxia, ensuring appropriate cell function and survival. Hypoxia is the condition in which insufficient oxygen reaches the body's tissues. It can be caused by a decrease in partial oxygen pressure (PO2) in the environment, problems with breathing and/or oxygen transport, …
Time-Stepping For Laser Ablation, Harihar Khanal, David Autrique, Vasilios Alexiades
Time-Stepping For Laser Ablation, Harihar Khanal, David Autrique, Vasilios Alexiades
Publications
Nanosecond laser ablation is a popular technique, applied in many areas of science and technology such as medicine, archaeology, chemistry, environmental and materials sciences. We outline a computational model for radiative and collisional processes occurring during ns-laser ablation, and compare the performance of various low and high order time-stepping algorithms.
Hydrodynamic Modeling Of Ns-Laser Ablation, David Autrique, Vasilios Alexiades, Harihar Khanal
Hydrodynamic Modeling Of Ns-Laser Ablation, David Autrique, Vasilios Alexiades, Harihar Khanal
Publications
Laser ablation is a versatile and widespread technique, applied in an increasing number of medical, industrial and analytical applications. A hydrodynamic multiphase model describing nanosecond-laser ablation (ns- LA) is outlined. The model accounts for target heating and mass removal mechanisms as well as plume expansion and plasma formation. A copper target is placed in an ambient environment consisting of helium and irradiated by a nanosecond-laser pulse. The effect of variable laser settings on the ablation process is explored in 1-D numerical simulations.
Models Of Phototransduction In Rod Photoreceptors, Harihar Khanal, Vasilios Alexiades
Models Of Phototransduction In Rod Photoreceptors, Harihar Khanal, Vasilios Alexiades
Publications
Phototransduction is the process by which photons of light generate an electrical response in retinal rod and cone photoreceptors, thereby initiating vision. We compare the electrical response in salamander rods from increasingly more (spacialy) detailed models of phototransduction: 0-dimensional (bulk), 1-dimensional (longitudinal), 2-dimensional (axisymmetric), and 3-dimensional (with incisures). We discuss issues of finding physical parameters for simulation and validation of models, and also present some computational experiments for rods with geometry of mouse and human photoreceptors.
Multiphoton Response Of Retinal Rod Photoreceptors, Vasilios Alexiades, Harihar Khanal
Multiphoton Response Of Retinal Rod Photoreceptors, Vasilios Alexiades, Harihar Khanal
Publications
Phototransduction is the process by which light is converted into an electrical response in retinal photoreceptors. Rod photoreceptors contain a stack of (about 1000) disc membranes packed with photopigment rhodopsin molecules, which absorb the photons. We present computational experiments which show the profound effect on the response of the distances (how many discs apart) photons happen to be absorbed at. This photon-distribution effect alone can account for much of the observed variability in response.
Response Of Dark-Adapted Retinal Rod Photoreceptors, H. Khanal, V. Alexiades, E. Dibenedetto
Response Of Dark-Adapted Retinal Rod Photoreceptors, H. Khanal, V. Alexiades, E. Dibenedetto
Publications
The process of phototransduction, whereby light is converted into an electrical response, in rod and cone photoreceptors in the retina, involves as a key setp, the diffusion of the cytoplasmic, signaling molecules cGMP (cyclic guanosime monophosphate) and Ca2+ diffuse in the cytoplasm (the fluid surrounding the discs). the complex geometry of the rod creates computational difficulties. We present spatio-temporal compuational models for interacctions and diffusion of cGMP and Ca2+ in the cytoplasm of vertebrate rod photoreceptors, as well as numerical simulations fo the response to light of dark-adapted Salamander rods.
Computational Models For Diffusion Of Second Messengers In Visual Transduction, Harihar Khanal
Computational Models For Diffusion Of Second Messengers In Visual Transduction, Harihar Khanal
Publications
The process of phototransduction, whereby light is converted into an electrical response in retinal rod and cone photoreceptors, involves, as a crucial step, the diffusion of cytoplasmic signaling molecules, termed second messengers. A barrier to mathematical and computational modeling is the complex geometry of the rod outer segment which contains about 1000 thin discs. Most current investigations on the subject assume a well-stirred bulk aqueous environment thereby avoiding such geometrical complexity. We present theoretical and computational spatio-temporal models for phototransduction in vertebrate rod photoreceptors, which are pointwise in nature and thus take into account the complex geometry of the …