Medicine and Health Sciences Commons^™

Human Ipsc Derived Cardiomyocyte Model Reveals The Transcriptomic Bases Of Covid-19 Associated Myocardial Injury, Kashish Kumar, Satish Kumar, Erica De Leon, Joanne E. Curran, Sarah Williams-Blangero, John Blangero

Research Symposium

Background: Multi-organ complications have been the hallmark of severe COVID-19; cardiac injuries were reported in 20% to 30% of hospitalized COVID-19 patients, although the disease etiology remains poorly understood. This study leveraged genome-wide RNA-sequence data generated using induced pluripotent stem cell (iPSC) differentiated cardiomyocytes (CMs) and in vitro modeling of SARS-CoV-2 infection in CMs, to understand the molecular mechanisms of COVID-19 myocardial injuries for novel diagnostic and therapeutic development.

Methods: Raw RNA-sequence data sets, GSE165242 and GSE150392 were aligned to human genome assembly GRCh38 and gene expressions were quantified. Differentially expressed (DE) genes between experimental groups were identified using moderated …

Neutralizing Anti-Rbd Fraction For Sars-Cov-2 Is Associated With The Interaction Waist Circumference And Sex. An Esfuerso Preliminary Report On University Students, Juan C. Lopez-Alvarenga, Esperanza M. Garcia-Oropeza, Adriana L. Perales-Torres, Alvaro Diaz-Badillo, Lucia M. Perez-Navarro, Estrella Martinez-Lopez, Marisol Rosas-Diaz, Octelina Castillo-Ruiz, Laura Yanneth Ramirez-Quintanilla, Jacquelynne Cervantes, Edda Sciutto, Beatriz Tapia, Leonel Vela, Claudia Munguia-Cisneros, Carlos Ramirez-Pfeiffer

Research Symposium

In a previous study we reported that 25% of college students had a family history of type 2 diabetes (T2D), and 39% of hypertension. Interestingly, between 17 to 47% reported not knowing about T2D or hypertension, neither the existing obesity-metabolic problems (ESFUERSO study). The COVID-19 pandemic forced confinement and modifications in food intake, physical activity, and psychological stress. This study aimed to analyze if the immune Ig-G anti-RBD (protective epitope in S protein) response associated with type of vaccination, metabolic risk, perceived stress, and history of COVID-19 contacts.

We included 116 students at the 3th year of follow up in …

Cell-Based Experimental Evidence To The Anti-Covid-19 Potential Of Ashwagandha And Honeybee Propolis Ingredients, Renu Wadhwa, Durai Sundar, Yoshiyuki Ishida, Keiji Terao, Sunil C. Kaul

Research Symposium

Background: The COVID-19 pandemic emerged in December 2019 by a novel strain of SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) has led to new endeavours in repurposing of existing drugs, anti-COVID-19 vaccine and drug development. Natural products, due to their general safety and wider availability, have attracted research and public attention. In this study, we report anti-COVID potential of compounds from honeybee propolis and Ayurvedic herb, Ashwagandha. Effect of active ingredients was studied on human cell surface receptors (ACE-2:Angiotensin Converting Enzyme-2/Spike protein and TMPRSS2:Transmembrane Protease Serine 2), critical for virus infection and virus main protease (Mpro, essential for virus replication), …

Covid Smell Tracker: A Research-Based Mobile Application To Study Smell Loss In Subjects With Covid-19, John Pueringer, Matthew Brennan, Tory Mcknight, Mindy Rabinowitz, Elina Toskala, Gurston Nyquist, Marc Rosen, Aykut Unsal

Research Day

Introduction: Up to 60% of people infected with SARS-CoV-2 report anosmia or ageusia during their disease course. “COVID Smell Tracker” is a smart phone application (app) developed to elucidate the onset, duration and extent of anosmia and ageusia through questionnaires.

Methods: “COVID Smell Tracker” is publicly available on smart phone devices (www.covidsmelltracker.org). Users complete surveys around demographics, medical history, COVID status and symptomology. Deidentified responses were collated and analyzed using descriptive statistics.

Results: Of the 266 users included, the majority were located in Europe (43%) and North America (33%). Male, Caucasian users were most common (54.9% and 61.7% respectively), followed …

The Impact Of Covid-19 On Teledermatology, Cassandra Yeboah, Nailah Harvey, Rohan Krishnan, Jules B. Lipoff

Research Day

The accelerated implementation and use of teledermatology during COVID-19 has been met with successes and challenges. This review explores first, how telemedicine was utilized in dermatology prior to the pandemic, the regulatory adaptions made in response to the pandemic and the effectiveness of the rapid implementation of teledermatology during COVID-19, and finally, how teledermatology has expanded in response to the pandemic. In sum, this review examines lessons learned, how teledermatology’s reliance on digital technologies might paradoxically exacerbate healthcare disparities, and considers the future outlook. Prior to COVID-19, teledermatology was limited due to decreased insurance reimbursement for telemedicine visits, concern about …

Rapid Return To Normal Activities At A Residential Summer Camp During Covid-19 Pandemic, Anna Klunk, Rachel Holloway, Arash Babaoff, Eric Jelin

Research Day

Aim: Infection prevention and control (IPC) within residential settings is a central focus of the coronavirus disease 2019 (COVID-19) pandemic. Youth residential summer camps are an excellent model for such environments and have thus far had mixed results. The aim of this report is to describe the successful implementation of a seven-week overnight summer camp with rapid return to normal activities from June to August 2020

Subjects and Methods: This retrospective study includes 427 individuals who traveled from 24 US States. All staff and campers were tested by serial nasopharyngeal PCR tests in the context of strict infection prevention and …

Assessment Of Patient And Employee Mental Health During Covid-19, Lanerica Rogers, Tammy Phillips, Aerial Petty, Gabriana Freire, Carline Denis-Barnes

Research Day

Background: Many individuals in the United States have anecdotally reported a decline in their mental health due to worry and stress over the COVID-19 pandemic. Although much research has been dedicated to populations across the country, patients and employees at community health centers have been overlooked in terms of the effect of pandemic conditions on their mental health. The present study seeks to understand how the mental health of these populations has been impacted and offer recommendations for what can be done to address any unmet mental health needs.

Methods: Survey responses were compiled from patients and employees of the …

Training New Providers Dobhoff Tube Insertion During Covid-19: Rapid Training And A Novel “Opt In” Approach To Learning, Michele Decastro, Msn, Crnp, Heather M. Etzl, Msn, Rn, Cbc, Jacqueline E. Crawford, Ms, Rn, Accns-P

House Staff Quality Improvement and Patient Safety Conference (2020-)

As increasing numbers of Covid-19 patients were admitted to the hospital and progressed thru their disease course, the Division of Hospital Medicine noted an increased need for enteral feeding access for their patients. At the same time, the Nutritional Support Clinical Nurse Specialists were seeing an increase in requests for assistance with use of Cortrak technology for insertion of Dobhoff tube (DHT) insertion for high risk patients diagnosed with Covid-19.