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Full-Text Articles in Medicine and Health Sciences
Association Of Vitamin D Receptor Cdx-2 Polymorphism With Covid-19: A Case-Control Study, Mahmoud M. Alseoudy, Maha O. Hammad, Mohmed Elgamal, Dalia A. Abdelghany, Asmaa M. Borg, Ahmed El-Mesery, Dina Elzeiny
Association Of Vitamin D Receptor Cdx-2 Polymorphism With Covid-19: A Case-Control Study, Mahmoud M. Alseoudy, Maha O. Hammad, Mohmed Elgamal, Dalia A. Abdelghany, Asmaa M. Borg, Ahmed El-Mesery, Dina Elzeiny
Mansoura Medical Journal
Background: Host genetic variability has been suggested as an important explanation for inter-individual differences in COVID-19 susceptibility and severity. Most vitamin D actions in the regulation of immunity are mediated by vitamin D receptors (VDRs). Polymorphisms in the VDR gene have been associated with several health outcomes; however, their effects on COVID-19 still need more clarification. This study aims to investigate the association of the VDR SNP (rs11568820, Cdx-2) with susceptibility and inter-individual variability of the severity of COVID-19. Methods: A total of 100 confirmed COVID-19 patients and 100 age and sex-matched controls were enrolled in this study between July …
Outcome Of Covid-19 In Patients With Rheumatic Diseases Treated With Immunosuppressive Drugs, Ali Sobh, Noha Hazem Elnagdy, Mohamed Elegezy, Mohamed Mofreh, Mohamed Tohlob, Ahmad M. Eita, Ragheed Rizk, Ola Eliwa, Marwa H. Elnagdy, Ahmed Elsaeed Abdulgalil
Outcome Of Covid-19 In Patients With Rheumatic Diseases Treated With Immunosuppressive Drugs, Ali Sobh, Noha Hazem Elnagdy, Mohamed Elegezy, Mohamed Mofreh, Mohamed Tohlob, Ahmad M. Eita, Ragheed Rizk, Ola Eliwa, Marwa H. Elnagdy, Ahmed Elsaeed Abdulgalil
Mansoura Medical Journal
Background: Rheumatologic disorders have been significantly impacted by the coronavirus disease 2019 (COVID-19) pandemic. The potential role of immunosuppressive drugs in the presentation, severity and even management of COVID-19 is still questionable. The aim of this work was to study the effect of immunosuppressive drugs on outcome of COVID-19 infection in patients with rheumatic diseases. 109 rheumatic patients (37 pediatrics and 72 adults) taking immunosuppressive treatment with confirmed COVID-19 infection were included in this study. Clinical, laboratory, radiological findings and outcome of these patients were retrospectively retrieved from hospital medical records. Results: The majority of adult cases were rheumatoid arthritis …