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Full-Text Articles in Medicine and Health Sciences
Subcutaneous Neurotophin 4 Infusion Using Osmotic Pumps Or Direct Muscular Injection Enhances Aging Rat Laryngeal Muscles, Richard D. Andreatta, Joseph C. Stemple, Tanya S. Seward, Colleen A. Mcmullen
Subcutaneous Neurotophin 4 Infusion Using Osmotic Pumps Or Direct Muscular Injection Enhances Aging Rat Laryngeal Muscles, Richard D. Andreatta, Joseph C. Stemple, Tanya S. Seward, Colleen A. Mcmullen
Physical Therapy Faculty Publications
Laryngeal dysfunction in the elderly is a major cause of disability, from voice disorders to dysphagia and loss of airway protective reflexes. Few, if any, therapies exist that target age-related laryngeal muscle dysfunction. Neurotrophins are involved in muscle innervation and differentiation of neuromuscular junctions (NMJs). It is thought that neurotrophins enhance neuromuscular transmission by increasing neurotransmitter release. The neuromuscular junctions (NMJs) become smaller and less abundant in aging rat laryngeal muscles, with evidence of functional denervation. We explored the effects of NTF4 for future clinical use as a therapeutic to improve function in aging human laryngeal muscles. Here, we provide …
Bk Channels Mediate Synaptic Plasticity Underlying Habituation In Rats, Tariq Zaman, Cleusa De Oliveira, Mahabba Smoka, Chakravarthi Narla, Michael O. Poulter, Susanne Schmid
Bk Channels Mediate Synaptic Plasticity Underlying Habituation In Rats, Tariq Zaman, Cleusa De Oliveira, Mahabba Smoka, Chakravarthi Narla, Michael O. Poulter, Susanne Schmid
Anatomy and Cell Biology Publications
Habituation is a basic form of implicit learning and represents a sensory filter that is disrupted in autism, schizophrenia, and several other mental disorders. Despite extensive research in the past decades on habituation of startle and other escape responses, the underlying neural mechanisms are still not fully understood. There is evidence from previous studies indicating that BK channels might play a critical role in habituation. We here used a wide array of approaches to test this hypothesis. We show that BK channel activation and subsequent phosphorylation of these channels are essential for synaptic depression presumably underlying startle habituation in rats, …
Effects Of Nigella Sativa And Hypericum Perforatum On Wound Healing, Mehmet Cengi̇z Han, Ali̇ Sai̇d Durmuş, Aydin Sağliyan, Ci̇han Günay, Mustafa Özkaraca, Fati̇h Mehmet Kandemi̇r, Seli̇m Çomakli, Di̇cle Firat Öztopalan
Effects Of Nigella Sativa And Hypericum Perforatum On Wound Healing, Mehmet Cengi̇z Han, Ali̇ Sai̇d Durmuş, Aydin Sağliyan, Ci̇han Günay, Mustafa Özkaraca, Fati̇h Mehmet Kandemi̇r, Seli̇m Çomakli, Di̇cle Firat Öztopalan
Turkish Journal of Veterinary & Animal Sciences
In this study, it was aimed to determine the influence of applying Nigella sativa (NS) and Hypericum perforatum (HP) on wound healing. A total of 42 female albino 2-month-old Wistar rats were randomly separated into 3 main groups. Each of these main groups was separated into two subgroups for 7- and 14-day postoperative follow-ups. A total of 84 excisional skin wounds, 5 mm in diameter, were created on the backs of the rats. Placebo cream (control group), 50% NS oil cream, and 50% HP oil cream were applied topically for the first, second, and third group, respectively. The wounds were …
Investigation Of Effects Of Fucoidan Polysaccharides Extracted From Twospecies Of Padina On The Wound-Healing Process In The Rat, Moazameh Kordjazi, Bahareh Shabanpour, Ebrahim Zabihi, Mohammad Ali Faramarzi, Hassan Ahmadi Gavlighi, Seyed Mohammad Amin Feghhi, Seyed Abbas Hosseini
Investigation Of Effects Of Fucoidan Polysaccharides Extracted From Twospecies Of Padina On The Wound-Healing Process In The Rat, Moazameh Kordjazi, Bahareh Shabanpour, Ebrahim Zabihi, Mohammad Ali Faramarzi, Hassan Ahmadi Gavlighi, Seyed Mohammad Amin Feghhi, Seyed Abbas Hosseini
Turkish Journal of Veterinary & Animal Sciences
Seaweeds contains different types of polysaccharides with high abilities. The aim of this study was to determine the potential of fucoidan polysaccharides for wound-healing properties. Fucoidans of two species of Padina (P. tetrastromatica and P. boergesenii), collected from the Persian Gulf northern coastal area, were extracted and analyzed using high-performance anion-exchange chromatography. Purified fucoidans were used to prepare a 2% topical ointment. Under aseptic conditions, two identical paravertebral full-thickness skin wounds (either by burn or excision) were made in 40 anesthetized male rats allocated into 4 groups. Either fucoidan ointments or the vehicle (ointment base) were applied to rats' wounds …
Effects Of Ketamine On Monoamine Neurotransmittersand Gaba In Embryonic Neurocytes From Fetal Rat, Xinran Li, Mo Liu, Yue Li, Cen Guo, Lina Li, Yanan Li, Yuxin Wang, Yiming Zhang, Li Gao
Effects Of Ketamine On Monoamine Neurotransmittersand Gaba In Embryonic Neurocytes From Fetal Rat, Xinran Li, Mo Liu, Yue Li, Cen Guo, Lina Li, Yanan Li, Yuxin Wang, Yiming Zhang, Li Gao
Turkish Journal of Veterinary & Animal Sciences
The effect of ketamine, a drug commonly used as an anesthetic, on monoaminergic neurotransmitters and GABA in neurocytes from fetal rats has not yet been elucidated. We thus decided to investigate these effects by first evaluating ketamine levels in the cerebrospinal fluid by high-performance liquid chromatography. We thus determined the concentrations of GABA, DA, NE, 5-HT, and 5-HIAA following the addition of four different concentrations of ketamine at day 7 of nerve cell culture. GABA, 5-HT, and 5-HIAA levels were increased after an initial decrease: they showed the lowest levels at 10-15 min and the highest peaks at 45-90 min, …
Ultrastructure Of Rat Umbilical Cord Stroma-Derived Mesenchymal Stem Cells, Ahmet Ceylan, Özge Özgenç, Korhan Altunbaş, Petek Korkusuz, Asuman Özen
Ultrastructure Of Rat Umbilical Cord Stroma-Derived Mesenchymal Stem Cells, Ahmet Ceylan, Özge Özgenç, Korhan Altunbaş, Petek Korkusuz, Asuman Özen
Turkish Journal of Veterinary & Animal Sciences
Being multipotent progenitor cells, mesenchymal stem cells continue to attract attention as a promising tool for cell-based therapy and tissue engineering. However, research on the ultrastructure of these cells is rather scarce. This study was aimed at the investigation of the transmission electron microscopic ultrastructure and morphology of mesenchymal stem cells isolated from the stroma of rat umbilical cord using the explant culture method. At the end of the third passage, some of the cells isolated from the stroma of the umbilical cord were harvested for electron microscopic examination. The remaining cells were induced for osteogenic, chondrogenic, and adipogenic differentiation. …