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The Role Of The Nef Protein In Mhc-I Downregulation And Viral Immune Evasion By Hiv-1, Hannah Elliott, Gerard F. Hoyne
The Role Of The Nef Protein In Mhc-I Downregulation And Viral Immune Evasion By Hiv-1, Hannah Elliott, Gerard F. Hoyne
Health Sciences Papers and Journal Articles
The Nef protein is a major determinant of pathogenicity caused by the human immunodeficiency virus (HIV) and is encoded by the nef gene within the genomes of primate lentiviruses HIV-1, HIV-2 and simian immunodeficiency virus (SIV). The HIV Nef protein subverts the intracellular membrane traffic to mediate endocytosis of a number of cell surface receptors to accelerate their degradation. In this review we will examine how the multifunctional Nef can mediate down regulation of the Major histocompatibility Complex (MHC) I complex proteins from the surface of infected cells as a means of immune evasion by HIV. By selectively downregulating MHC-I …