Medicine and Health Sciences Commons^™

387. Gene Delivery Of Apoe2 Reduces Amyloid Pathology In Transgenic Mouse Models Of Alzheimer's Disease, Lingzhi Zhao, Andrew J. Gottesdiener, Mayur S. Parmar, Christine Grevstad, David Havlicek, Jonathan Rosenberg, Stephen Kaminsky, Maria Chiuchiolo, Dolan Sondhi, Ronald G. Crystal, Steven M. Paul

HPD Articles

The deposition of amyloid β-peptides (Aβ), cleavage products of the amyloid precursor protein (APP) by β- and γ-secretases, in brain represents a pathological hallmark of Alzheimer's disease (AD). Apolipoprotein E (APOE) ε4 allele carriers have an increased risk to develop AD and an earlier age of onset, whereas carriers of the ε2 allele have reduced risk and a delayed age of onset. APOE is also a major determinant of brain Aβ and amyloid burden in humans and in several transgenic mouse models of AD (E4>E3>E2). We have previously reported that lentivirus-mediated intraparenchymal gene delivery of APOE2 significantly reduces …

Focus On Microscopy Fom 2006-2015 Abstracts, George Mcnamara

George McNamara

Focus On Microscopy FOM 2006-2015 abstracts

FOM's are cutting edge microscopy meetings. Their abstracts are posted online soon after the meeting. FOM2015's abstracts are at http://www.focusonmicroscopy.org/2015/program.html

I have been downloading the single PDF abstracts, and making a single large PDF. every year. I figure the "annual organized" PDF may be useful to others, so am posting a ZIP file here containing: FOM 2006 FOM 2007 FOM 2008 FOM 2009 FOM 2010 FOM 2011 FOM 2012 FOM 2013 FOM 2014 FOM 2015 I note the abstracts do not contain copyright notices, but anyone using should "give credit where credit is due" …