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Articles 1 - 7 of 7
Full-Text Articles in Medicine and Health Sciences
Novel Role Of Antioxidant-1 (Atox1) As A Copper-Dependent Transcription Factor Involved In Cell Proliferation, S. Itoh, H. W. Kim, O. Nakagawa, K. Ozumi, Susan M. Lessner, H. Aoki, K. Akram, R. D. Mckinney, M. Ushio-Fukai, T. Fukai
Novel Role Of Antioxidant-1 (Atox1) As A Copper-Dependent Transcription Factor Involved In Cell Proliferation, S. Itoh, H. W. Kim, O. Nakagawa, K. Ozumi, Susan M. Lessner, H. Aoki, K. Akram, R. D. Mckinney, M. Ushio-Fukai, T. Fukai
Faculty Publications
Copper plays a fundamental role in regulating cell growth. Many types of human cancer tissues have higher copper levels than normal tissues. Copper can also induce gene expression. However, transcription factors that mediate copper-induced cell proliferation have not been identified in mammals. Here we show that antioxidant-1 (Atox1), previously appreciated as a copper chaperone, represents a novel copper-dependent transcription factor that mediates copper-induced cell proliferation. Stimulation of mouse embryonic fibroblasts (MEFs) with copper markedly increased cell proliferation, cyclin D1 expression, and entry into S phase, which were completely abolished in Atox1-/- MEFs. Promoter analysis and EMSA revealed that copper …
A Call For A Statewide Bioinformatics Institute, John R. Rose
A Call For A Statewide Bioinformatics Institute, John R. Rose
Journal of the South Carolina Academy of Science
No abstract provided.
Sc Inbre: A Catalyst For Biomedical Research Development In South Carolina, Lucia A. Pirisi-Creek M.D, Scott Little, Ph.D.
Sc Inbre: A Catalyst For Biomedical Research Development In South Carolina, Lucia A. Pirisi-Creek M.D, Scott Little, Ph.D.
Journal of the South Carolina Academy of Science
No abstract provided.
Editorial, First Science And Policy Issue, Jscas
Editorial, First Science And Policy Issue, Jscas
Journal of the South Carolina Academy of Science
No abstract provided.
Inflammation: The Key To Health And Disease, Prakash Nagarkatti Ph. D, Donald J. Dipette M. D.
Inflammation: The Key To Health And Disease, Prakash Nagarkatti Ph. D, Donald J. Dipette M. D.
Journal of the South Carolina Academy of Science
No abstract provided.
Solution Chemical Synthesis Of Nanostructured Thermoelectric Materials, Xiaohua Ji, Terry M. Tritt, Xinbing Zhao, Joe W. Kolis
Solution Chemical Synthesis Of Nanostructured Thermoelectric Materials, Xiaohua Ji, Terry M. Tritt, Xinbing Zhao, Joe W. Kolis
Journal of the South Carolina Academy of Science
No abstract provided.
With The Help Of South Carolina Research Universities, Scra Demonstrates Leadership In Applied Research And Commercialization Within Sc, Bill Mahoney
Journal of the South Carolina Academy of Science
No abstract provided.