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Full-Text Articles in Medicine and Health Sciences

The Cd154/Cd40 Interaction Required For Retrovirus-Induced Murine Immunodeficiency Syndrome Is Not Mediated By Upregulation Of The Cd80/Cd86 Costimulatory Molecules, Kathy A. Green, W. James Cook, Arlene H. Sharpe, William R. Green Nov 2002

The Cd154/Cd40 Interaction Required For Retrovirus-Induced Murine Immunodeficiency Syndrome Is Not Mediated By Upregulation Of The Cd80/Cd86 Costimulatory Molecules, Kathy A. Green, W. James Cook, Arlene H. Sharpe, William R. Green

Dartmouth Scholarship

C57BL/6 (B6) mice infected with LP-BM5 retroviruses develop disease, including an immunodeficiency similar to AIDS. This disease, murine AIDS (MAIDS), is inhibited by in vivo anti-CD154 monoclonal antibody treatment. The similar levels of insusceptibility of CD40−/− and CD154−/− B6 mice indicate that CD154/CD40 molecular interactions are required for MAIDS. CD4+ T and B cells, respectively, provide the CD154 and CD40 expression needed for MAIDS induction. Here, the required CD154/CD40 interaction is shown to be independent of CD80 and CD86 expression: CD80/CD86−/− B6 mice develop MAIDS after LP-BM5 infection.


Analysis Of The Crude Antigen Of Hymenolepis Nana From Mice By Sds-Page And The Determination Of Specific Antigens In Protein Structure By Western Blotting, Bahadir Gönenç Jan 2002

Analysis Of The Crude Antigen Of Hymenolepis Nana From Mice By Sds-Page And The Determination Of Specific Antigens In Protein Structure By Western Blotting, Bahadir Gönenç

Turkish Journal of Veterinary & Animal Sciences

Protein bands of crude antigens of Hymenolepis nana were determined by SDS-PAGE and Western blotting. Thirty Swiss albino mice were allotted into two groups of 15 each as positive (infected with H. nana) and negative (non-infected with H. nana) groups. The natural infections of H. nana and other helminths were determined by centrifugal flotation of faeces. After bleeding, the mice were necropsied and their guts were examined for H. nana and other intestinal helminths. Sera from mice were tested by Western blotting and the bands obtained from positive and negative groups were compared. The specific protein band for H. nana …


The Effect Of Trifolium Pratense On Spermatogenesis And Its Acute Toxicity (Ld_{50}) In Mice, Tülay Bakirel, Oya Keleş, H. Hakan Bozkurt, Kemal Ak Jan 2002

The Effect Of Trifolium Pratense On Spermatogenesis And Its Acute Toxicity (Ld_{50}) In Mice, Tülay Bakirel, Oya Keleş, H. Hakan Bozkurt, Kemal Ak

Turkish Journal of Veterinary & Animal Sciences

Trifolium pratense contains phytoestrogens and thus it has estrogenic activity. Estrogen has an important role in the development of the reproductive system and the maintanence of its function, and for this reason the effect of Trifolium pratense on sperm parameters and spermatogenesis was examined. Furthermore, its acute toxicity was established. In this study, the motility and morphology of epididymal spermatozoa taken from animals fed diets contains 20% and 40% Trifolium pratense, were affected. Statistically insignificant differences in the diameter of the seminiferous tubule and the number of primary spermatocytes between the control and experimental groups were observed. Intraperitoneal LD_{50} was …


The Effects Of An Electromagnetic Field (60-90 Hz And 5 Mt) On Blood Electrolyte Levels In Diurnal Rhythm, Gökhan Eraslan, Mehmet Akdoğan, Ali̇ Bi̇lgi̇li̇, Murat Kanbur, Fatma Şahi̇ndokuyucu Jan 2002

The Effects Of An Electromagnetic Field (60-90 Hz And 5 Mt) On Blood Electrolyte Levels In Diurnal Rhythm, Gökhan Eraslan, Mehmet Akdoğan, Ali̇ Bi̇lgi̇li̇, Murat Kanbur, Fatma Şahi̇ndokuyucu

Turkish Journal of Veterinary & Animal Sciences

In this study, 120 British male mice, weighing 35-40 g, and 5 months old were used. Three groups, one control (Group I) and two experimental (Groups II and III), were formed. One experimental group (Group II) received 60 Hz and 5 mT, while the other (Group III) received 90 Hz frequency and 5 mT magnetic flux density efficacy electromagnetic field (EMF), between 900 and 1700. During this period, blood was taken every hour and blood electrolyte levels (Ca^{++}, P^{+++}, Na^{+}, K^{+}, Cl^{-}) were evaluated. In conclusion, in almost all periods and groups only sodium and calcium levels showed a steady …


Effects Of Alcohol, Passive Smoking And Alcohol Plus Passive Smoking On Some Serum Biochemical Variables In Mice, Mustafa Altinişik, Muharrem Balkaya, Funda Kargin, Hümeyra Ünsal, Cengi̇z Ünsal Jan 2002

Effects Of Alcohol, Passive Smoking And Alcohol Plus Passive Smoking On Some Serum Biochemical Variables In Mice, Mustafa Altinişik, Muharrem Balkaya, Funda Kargin, Hümeyra Ünsal, Cengi̇z Ünsal

Turkish Journal of Veterinary & Animal Sciences

The effects of alcohol, passive smoking and alcohol+passive smoking on certain biochemical variables were investigated in mice serum. For this purpose, 72 female and 49 male Swiss albino mice were used. The animals were approximately 10 weeks old at the beginning of the experiment and their initial body weights ranged from 22 to 31 g. All animals were divided randomly into four groups; the control, alcohol, passive smoking and alcohol+passive smoking groups. Alcohol was given in drinking water at a v/v ratio of 10% during the first week, 20% during the second week and 30% during the following four weeks. …


Visceral Larva Migrans In Mice Caused By Eating Toxocara Canis-Infected Chick Livers, Erkut Tüzer, Müfi̇t Toparlak, Ayşen Gargili, Aynur Gülanber, Vedat Keleş, İlker Efi̇l, Meltem Ulutaş Esatgi̇l Jan 2002

Visceral Larva Migrans In Mice Caused By Eating Toxocara Canis-Infected Chick Livers, Erkut Tüzer, Müfi̇t Toparlak, Ayşen Gargili, Aynur Gülanber, Vedat Keleş, İlker Efi̇l, Meltem Ulutaş Esatgi̇l

Turkish Journal of Veterinary & Animal Sciences

In this study, two subjects, 1) whether Visceral Larva Migrans (VLM) takes place when T. canis larvae-infected chick livers are eaten and 2) whether any differences are present between larval distributions, clinical signs and pathological disorders of the infections caused by eggs and infected liver, were investigated in the chick-mouse model. For this purpose, 15-day-old broiler chicks (n=42) and 3-month-old albino mice (n=62) were used. Thirty chicks were each infected orally with 5000 infective T.canis eggs. These chicks, composed of 6 groups, were necropsied at 2-day intervals and their livers were fed to 42 mice in 6 experimental groups. In …