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Full-Text Articles in Medicine and Health Sciences
The Human Intruder Test: An Anxiety Assessment In Rhesus Macaques (Macaca Mulatta), Emily J. Peterson
The Human Intruder Test: An Anxiety Assessment In Rhesus Macaques (Macaca Mulatta), Emily J. Peterson
Masters Theses
The human intruder test (HIT) is a noninvasive tool widely used for assessing anxiety in rhesus macaques (Macaca mulatta). This thesis explores the HIT procedure and applies it to a population of monkeys with a self-injurious behavioral pathology. Individual variation on this test can be used to assess anxiety and temperament. The first experiment of this thesis applied two different procedures of the HIT to 17 monkeys at UMass. Monkeys displayed little response to the intruder, and no significant differences were detected for the two procedures. To determine whether these responses were unique to the UMass monkeys, their …
Intracranial Infusions Of Neurotensin Agonists Produce An Anxiolytic Profile In A Rat Ultrasonic Vocalization Model, Floyd F. Steele Iii
Intracranial Infusions Of Neurotensin Agonists Produce An Anxiolytic Profile In A Rat Ultrasonic Vocalization Model, Floyd F. Steele Iii
All NMU Master's Theses
Neurotensin (NT) is a peptide neurotransmitter that interacts with brain monoamine neurotransmitter systems. It has been demonstrated that neurotensin type 1 and type 2 receptor agonists influence animal models of psychological disorders and pain regulation, respectively. It has already been shown that the systemic administration of the selective neurotensin type 1 receptor agonist PD149163 can attenuate the number of fear-induced 22-kHz ultrasonic vocalizations (USVs) produced by male Wistar rats. A reduction in the number of 22-kHz USV calls is indicative of an anxiolytic effect. The current study used a USV model to evaluate the effects of PD149163 (0.1, 1.0, and …
Effects Of Acute Nicotine On Larval Zebrafish Exploratory Behavior In A Complex Environment, Brandon Chen
Effects Of Acute Nicotine On Larval Zebrafish Exploratory Behavior In A Complex Environment, Brandon Chen
Senior Projects Spring 2015
The larval zebrafish is emerging as a useful model to assess neurobehavioral toxicity. A variety of behavioral assays have been developed to characterize normal behavior and the acute and chronic effects of a variety of compounds. To date, such behavioral assays have been limited to relatively simple behavioral measures (e.g., swimming activity in a single well). The present experiment describes methodology to assess exploratory behavior in 5 days-post-fertilization (5 dpf) larval zebrafish using a six-chamber, complex well-plate. In addition, the effect of acute nicotine exposure on exploratory activity in this complex environment was examined. Five dpf TU strain larvae were …