Medicine and Health Sciences Commons^™

Computational Analysis Of O6-Methylated Guanine And Thioguanine Complexes, Kirsten Stinson, Michael Bowman

Lux et Fides: A Journal for Undergraduate Christian Scholars

DNA methylation occurring on the O⁶ position of guanine has been linked to the formation of cancer. DNA complexes with O⁶-methylated guanine have been studied experimentally, yet questions remain concerning the carcinogenic properties of O⁶-methylguanine. This present research explored the interaction between O⁶-methylguanine and its potential nucleobase pairs of cytosine and adenine in hopes of elucidating the mutagenic characteristics of O⁶-methylguanine. A variety of computational methods including Density Functional Theory (DFT), Symmetry Adapted Perturbation Theory (SAPT), Noncovalent Interaction (NCI) analysis, and Natural Bond Orbital (NBO) analysis were employed to comprehensively probe …

Comparative Analysis Of Doxycycline And Ayurvedic Herbs To Target Metastatic Breast 2 Cancer: An In-Silico Approach, Acharya Balkrishna, Rashmi Mittal, Rohan Malik, Hariom Verma, Kuldeep Singh Mehra, Hariom Chaturvedi, Okeshwar Okeshwar, Swami Ishdev, Ajay Kumar, Vedpriya Arya

BioMedicine

Background: Metastasis of breast cancer cells to distant sites including lungs, liver, lymph node, brain and many more have substantially affected the overall survival outcome and distant metastasis free survival rate amongst the diseased individuals. Several pre-clinical and clinical studies were carried out to determine the potency of vigorous inhibitors but they extensively deteriorated the patient’s quality of life. Hence, there exists an urgent need to explore potent natural remedy to fight against metastatic breast cancer.

Methods: Ayurvedic medicinal plants documented in literature for their ability to fight against breast cancer was screened and their respective active moieties were evaluated …

In Vitro And In Silico Evaluation Of Andrographis Paniculata Ethanolic Crude Extracts On 3 Fatty Acid Synthase Expression On Breast Cancer Cells, Nur Amanina Johari, Nur Anisa Sapi’I, Alvin Lu Jiunn Hieng, Nurriza Ab Latif, Syazwani Itri Amran, Rosnani Hasham, Khairunadwa Jemon

BioMedicine

Background Fatty acid synthase (FASN), a key rate-limiting enzyme in the fatty acid biosynthesis pathway has been identified to be overexpressed in breast cancer. This overexpression has been affiliated with poor prognosis and resistance to chemotherapeutics. Consequently, FASN has come into focus as an appealing potential target for breast cancer treatment. Available FASN inhibitors, however, are unstable and have been correlated with adverse side effects. Objective This present study aims to investigate the potential of Andrographis paniculata ethanolic crude extract (AP) as a potent FASN inhibitor in breast cancer cells. Materials & Methods This study used MTT assay and flow …

Zinc Oxide Nanoparticles-Doped Curcumin-Assisted Recovery Of Rheumatoid Arthritis And Antioxidant Status In Experimental Rabbits, Shanza Azeez, Mishal Fatima, Ouz Gul, Huzaifa Rehman, Muhammad Aslam Shad, Haq Nawaz

BioMedicine

Introduction: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and synovial joint destruction.

Aims: The current study investigated the possible beneficial effect of zinc oxide nanoparticles-doped curcumin (ZnONPs-DC) on the recovery of RA and antioxidant status of experimental rabbits.

Methods: RA was induced in experimental rabbits by injecting complete Freund's adjuvant and collagen type-II emulsion (100 µL/kg body weight) in the base of their tail. Arthritic rabbits were orally treated with ZnONPs, curcumin, and ZnONPs-DC (250 µL/kg body weight). Serum samples from the control and study groups were collected before and after RA induction and after treatment. …

Protection Of Gueichih-Fuling-Wan On Cerebral Ischemia-Induced Brain Injury In Rodents Is Mediated By Trans-Cinnamaldehyde Via Inhibition Of Neuroinflammation And Apoptosis, Yuh-Fung Chen, Kuo-Jen Wu, Chi-Chung Kuo, Huei-Yann Tsai

BioMedicine

Background: Stroke is the leading cause of mortality and morbidity worldwide, and an effective therapeutic strategy for the prevention of patients with cerebral ischemiainduced brain injury is lacking. Traditional Chinese medicine with neuroprotective activities might be beneficial and provide alternative therapeutic opportunities for cerebral ischemia.Purposes: This study aimed to evaluate the neuroprotection and possible mechanisms of Gueichih-Fuling-Wan (GFW), its’ constitutive herbs, and their active compounds on cerebral ischemia/reperfusion (I/R)-induced brain injury in rodents.Methods: Various doses of extracts (0.25, 0.5, and 1.0 g/kg) of GFW and five constituent herbs (Cinnamomi Cortex, CC; Poria cocos, PC; Paeonia lactifloa, PL; Paeonia suffruticosa, PS …

Glutaminase - A Potential Target For Cancer Treatment, Josephine Anthony, Sureka Varalakshmi, Ashok Kumar Sekar, Nalini Devarajan, Balamurugan Janakiraman, Rajendran Peramaiyan

BioMedicine

The overexpression of glutaminase is reported to influence cancer growth and metastasis through glutaminolysis. Upregulation of glutamine catabolism is recently recognized as a critical feature of cancer, and cancer cells are observed to reprogram glutamine metabolism to maintain its survival and proliferation. Special focus is given on the glutaminase isoform, GLS1 (kidney type glutaminase), as the other isoform GLS2 (Liver type glutaminase) acts as a tumour suppressor in some conditions. Glutaminolysis linked with autophagy, which is mediated via mTORC1, also serves as a promising target for cancer therapy. Glutamine also plays a vital role in maintaining redox homeostasis. Inhibition of …

Unveiling The Power Of Flavonoids: A Dynamic Exploration Of Their Impact On Cancer Through Matrix Metalloproteinases Regulation, Peramaiyan Rajendran

BioMedicine

Cancer is a prominent contributor to mortality rates globally, with its progression and spread being the primary factors underlying this assertion. Despite advancements in cancer therapy, the existing therapeutic strategies are rendered useless as a result of their toxicity and the development of chemoresistance. Hence, it is imperative to assess alternate therapy modalities, and natural compounds present a promising prospect due to their demonstrated anticancer capabilities in several research models. This article provides an overview of the regulatory mechanisms involved in the expression of metalloproteinases (MMPs) and explores the potential therapeutic function of flavonoids as agents with anticancer activity that …

Phytochemical Composition Of Clinacanthus Nutans Based On Factors Of Environment, Genetics And Postharvest Processes: A Review, Nurul Hamizah Sabindo, Rusidah Mat Yatim, Kannan Thirumulu Ponnuraj

BioMedicine

Herpes simplex, varicella-zoster lesions, skin rashes, diabetes, snake bites and insect bites have all been treated by using Clinacanthus nutans (C. nutans). The pharmacological effects of C. nutans are influenced by the presence of terpenoids, flavonoids, alkaloids, phenolic acids, saponins, glycosides, steroids and tannins. This review focused on the phytochemical makeup, which varies geographically and is a subject of scarcely existing knowledge. C. nutans served as the primary search term, while the keywords “phytochemicals”, “chemical component” and “phytochemistry” were used to search the literature in the Google Scholar, PubMed, Scopus and Web of Science databases. The articles pertinent to the …

Effect Of Social Media On Shaping The Agenda Of The Communicator In The Jordanian Tv Channels, Amer Khaled Ahmad Dr, Hamza Mohammad Nahar, Maram Mohammad Naji Manajreh Dr

Middle East Journal of Communication Studies

The study aimed to assess the extent to which communicators at Jordanian television channels use social media platforms as an information source, and the impact of these platforms on their news and information selection priorities. This was achieved using a survey tool distributed on an equal quota sample of (150) communicators from Jordanian television channels (Jordan TV, AlMamlaka TV, Roya TV). The study found that all the study subjects used social media platforms as a source of information, with the "X platform (formerly Twitter)" being the most used platform. The statement "understanding the audience's interests and preferences to produce tailored …

Innovation In Bioinformatics: Recent Tools, Database And Involvement Of Artificial Intelligence, Aziz Ahmed, Mohd Shuaib, Abdulbasid Banga, Rizwan Ahmad

Indonesian Journal of Medical Chemistry and Bioinformatics

Bioinformatics has evolved in recent years into a crucial subject and a well-liked research area that is interconnected with many approaches and disciplines. The capacity of bioinformatics and its approaches to tackle challenging biological problems and promote research and development. There are various tools and database which are used in bioinformatics. AI is the capacity of a computational system to carry out various activities associated with intellectual beings and as a computer system's imitation of human intelligence processes. The bioinformatics applications with artificial intelligence have the capacity to annotate the data in the direction of logical conclusions. By combining AI …

Smear Layer Removal Using Two Different Ni-Ti Instruments With Two Different Irrigating Systems. An Invitro Study, Tasneem Mohamed Reyad, Wael Ahmed Hessein, Ahmed Abdelrahman Hashem Ah, Said Abd Elhafiz

Future Dental Journal

Objectives: To evaluate and compare smear layer removal in root canals instrumented with two single Ni-Ti rotary instruments with two different irrigating systems. Materials and Methods: Sixty recently extracted single-rooted mandibular premolars teeth were decoronated to a standardized length of 14 mm. Roots were divided into two main groups (n=30) according to the rotary NiTi file used for instrumentation either with One Shape (OS) file or with One Curve file (OC). Each main group was subdivided into three subgroups according to the methods used to agitate the irrigating solutions either sonically or ultrasonically as following: Group A was subdivided into …

A Potential Of Watercress Nasturtium Officinale Bioactive Compounds In Inhibiting Infectious Myonecrosis Virus (Imnv) By Targeting Rna-Dependent Rna Polymerase (Rdrp) Virus From Several Countries: In Silico Approach, Qurrota A’Yunin, Fatchiyah Fatchiyah, Maftuch Maftuch, Feri Eko Hermanto, Muhammad Hermawan Widyananda, Narendra Santika Hartana, Muhaimin Rifa’I, Yoga Dwi Jatmiko

Karbala International Journal of Modern Science

Infectious myonecrosis virus (IMNV) disease causes mass mortality and decreased shrimp production. The RdRp region projects to the interior, where it may function in transcription. The focus of this study was to determine the effect of amino acid polymorphisms from several countries on the structure of RdRp and identify the potential of watercress in inhibiting IMNV by targeting the RdRp protein of IMNV through an in silico approach. The results showed that the structure of the IMNV RdRp protein from Indonesia was similar to Mexico, and the protein structure from India_QDN was identical to India_QIL. Ligand binding affinity values showed …

The Dependence Level Among Adolescent Vape Users: A Cross-Sectional Study, Violette Abo Karnib, Ghenwa Abedallhalim, Adam Ikkawi, Housam A. Saad, Hiba Deek

BAU Journal - Health and Wellbeing

Vape is a battery-powered device that works by heating a liquid called “e-liquid”. The use of vape has significantly increased in the past years among high and middle school students. The aim of the current study was to evaluate the level of dependence among adolescent vape users in Lebanon and to assess their knowledge about vape health hazards. A descriptive cross-sectional study with a self-administered questionnaire. A link for the survey was generated on Google Forms and sent to adolescents in the community. The survey was sent to parents of vape users and after their approval, it was shared with …

An Observational, Retrospective, Study To Assess Sehetna Wellness Program Impact On Employees’ Well-Being And Health, Wafaa Saeed, Lina Shaker, Laila Ghanem, Mohamed El Aziz, Omer Mostafa, Rabab Youssef

BAU Journal - Health and Wellbeing

Wellness is an ongoing process that leads to realizing one's full potential, with studies showing reduced inpatient admissions, healthcare costs, and improved health-related quality of life through participation in large-scale wellness programs. SEHETNA program is a wellness initiative conducted with the Egyptian Group for Import and Export (EGMED) to enhance employees’ well-being. This study aimed to assess the SEHETNA wellness program impact on the general health of employees. This is a retrospective descriptive observational study including employees enrolled in wellness program for up to 12-months in 2021. Data were entered and analyzed using SPSS. Descriptive analysis was done, categorical variables …

Knowledge, Attitude, And Experience Of Lebanese Females Toward Oral Contraceptive Use, Nisrine Al Rifaii, Chaza Alaeddine, Souraya Domiati, Abdalla El-Lakany

BAU Journal - Health and Wellbeing

Family planning is a key to slow unsustainable population growth and the resulting negative impacts on the national development efforts. Birth control pills or oral contraceptives are commonly used among childbearing-age women for family planning. Accordingly, this study aimed to evaluate the knowledge, attitude, and experience of oral contraceptive use among Lebanese women. A descriptive, cross-sectional, questionnaire-based study was conducted in Beirut and suburbs in 2018. The questionnaire included sociodemographic information consisting of age, educational level, occupation, marital status, and past medical history. It also included four different sections describing the pattern of use of oral contraceptives, attitude, knowledge, and …

The Psychological Conditions Of Pregnant Women During The Covid-19 Outbreak In Lebanon, Ibrahim Kadamani, Ali Samaha, Maya Gebbawi, Najwa Yahfoufi, Hanadi Mohamad Nur Steitiyeh, Abbas Samaha

BAU Journal - Health and Wellbeing

In Lebanon, the psychological conditions of pregnant women during the COVID-19 pandemic have not been reported, which creates the need to conduct this study that aims to evaluate the psychological conditions of pregnant women during the COVID-19 pandemic. A cross-sectional design was adopted to reach the aim of this study. The study sample was reached through OBS/GYN clinics to be able to contact the pregnant women in the community, where a convenient sampling technique was followed. The total number of participants was 360 pregnant women: 101 (27.77%) first trimester, 140 (38.88%) second trimester, and 119 (33.33%) third trimester. There is …

Improving Healthcare Workers’ Biohazardous Spill Safe Handling Skills, Zeina Mhanna, Ahmad Tassi

BAU Journal - Health and Wellbeing

All healthcare workers (HCWs) are exposed to biohazardous material. Biohazardous material may come in the form of spills, posing a risk of infection to (HCWs) who are not trained on how to safely handle them. While international guidelines recommend training HCWs on how to safely handle biohazardous spills in order to improve their skills, there are no studies that tackled this recommendation. The aim of this study is to improve HCWs’ biohazardous spill safe handling skills through training, and to evaluate the association between the HCWs’ improvement level and demographical characteristics. The study was conducted in a Southern Lebanese hospital …

In Football Players With Scaphoid Fractures, How Does Surgical Intervention Compare To A Conservative Intervention For The Outcomes Of Repair? A Critically Appraised Topic, Kaitlin Brun, Meggan Bartok, Caitlin Craig, Ally Smith

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

CLINICAL SCENARIO

Scaphoid injuries are common in high impact or high collision sports with 11% of all hand injuries and 60%-70% of all carpal injuries being attributed to the scaphoid bone. Athletes at the highest risk include males ages 20-24 years of age and those who participate in football, basketball, or ice hockey. Fracture of the scaphoid are often misdiagnosed which increase the chance of a nonunion fracture. Currently most scaphoid fractures are treated either conservatively or with surgical interventions. The increasing knowledge of this injury leads us to question the best treatment options for future football athletes.

Effectiveness Of Kinesio Tape In Treating Low Back Pain: A Critical Appraisal, Stacey Lansky, Sara Stiltner

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

CLINICAL SCENARIO

Low back pain is a musculoskeletal disorder that is expected to affect 80% of the population. ^2,7-8 There are several therapeutic interventions including modalities and rehabilitation exercises that have been used in standard treatment of low back pain to improve pain and disability. ^2,3,5,6,8,9 However, few studies have been done on the effects of Kinesio Tape (KT) on pain and disability in patients with low back pain. It should be a primary goal of clinicians treating patients with low back pain to understand if KT is an appropriate alternative intervention in treating pain and disability associated with low …

Athletic Trainers’ Knowledge And Perceived Ability Of Recognizing And Treating Panic Attacks, Caitlin Hill, Chyrsten Gessel, Jaclyn Tate

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE

Mental health is a condition of mental wellness that enables people to manage life's stressors, develop their potential, study and work effectively, and give back to their communities. One mental health condition is anxiety. Anxiety is the expectation of a threat in the future. There are multiple subtypes of anxiety disorders, including panic disorder with or without agoraphobia, generalized anxiety disorder (GAD), social anxiety disorder (SAD), specific phobias, separation anxiety, and panic disorder. This study investigates the relationship between ATs' knowledge and their perceived ability to identify and treat panic attacks.

Scapular Fracture In An Ice Hockey Player, Rachel N. Kornbluth, Art Mccreary, Aaron Lear

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE

Ice hockey is a fast and aggressive sport.^1-2 Due to deliberate collisions and fighting, a hard playing surface, and sharp skates, ice hockey players are at high and distinctive risk to injury.^2-5 The way in which ice hockey players collide with, or check, one another, makes the shoulder vulnerable. About 8.6-21.9% of injuries sustained in ice hockey involve the shoulder.⁴ Acromioclavicular joint sprains and anterior glenohumeral dislocations are most common.^1,4-5 This case presents a 25-year-old male collegiate ice hockey player who sustained a recurrent right-sided glenohumeral dislocation after being checked from behind with his arm …

Cpr Knowledge And Skill Retention Among Ncaa Division Iii Athletic Coaches: A Prospective Cohort Study, Allison Hanstine, Jaclyn Tate, Chyrsten Gessel

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE

It is crucial for athletic coaches to be proficient in CPR knowledge and skill performance for the health and safety of their athletes. This research aimed to assess CPR knowledge and CPR skill retention five months post-training among athletic coaches. In addition, the study assessed whether the number of years certified in CPR had an association with CPR skill performance scores five months post-training.

The Effectiveness Of Patient Education In A High School Setting, Noah Silvers, Laura L. Harris

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE

To compare different types of patient education when recommending best practices for the care of ankle sprains and concussions in adolescents.

Barriers To Implementation Of Post-Concussion Grade Exercise Tests, Tyler Beauregard

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE

The purpose of this study was to assess the potential barriers to sports physical therapy and athletic training clinicians implementing graded exertional tests, specifically for their patients following concussion.

Accuracy Of Ottawa Ankle Rules In Adolescent Foot And Ankle Injuries, Kalie Siereveld, Olivia Teague, Laura L. Harris

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE

To determine the effectiveness of Ottawa Ankle Rules (OAR) for informing physician referrals secondary to ankle and foot injuries within adolescents.

Quality Improvement Of A Post-Concussion Recovery Protocol, Halle Strege, Kaitlyn Burnham, Laura L. Harris

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE

To determine the effectiveness of a post-concussion recovery protocol in an adolescent athletic population.

An Investigation Of Aed Access In One Secondary School, Michelle Skaggs, Laura L. Harris

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE

To evaluate the accessibility and time required to retrieve and apply Automated External Defibrillators (AEDs) against established standards.

Athletic Trainer Confidence In The Management Of Abdominal Injuries And Gi Conditions, Emily C. Roberts, Janet E. Simon

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE

Inadequate evidence, position statements, clinical practice and post-surgical guidelines challenge athletic trainers’ capabilities to provide care for abdominal injuries and GI conditions.^1-4 The primary objective of this study is to assess athletic trainers’ confidence in the management and treatment of abdominal injuries and GI conditions compared to musculoskeletal injuries.

The Effect Of Task Demands On Decision Making In Dynamic, Sport-Like Virtual Environments, Jeromy Alt, Paula L. Silva, Tehran Davis, Adam W. Kiefer, Ryan Macpherson

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE

To determine if level of temporal pressure to arrive at a desired location explains decisions about passability of closing gaps between opponents encountered and how decisions change with task experience.

The Effect Of Ankle Foot Orthotics On Collegiate Athletes’ Sprint Biomechanics, Elizabeth A. Starns, Paige Tucker

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

OBJECTIVE

Carbon composite dynamic response ankle foot orthotics (CCDRAFOs) are lightweight ankle braces originally made to help pathologically involved legs walk more efficiently¹. Since CCDRAFOs are traditionally not used on able-bodied individuals, there is limited information on the effects of CCDRAFOs on sprint performance of able-bodied athletes. However, the technology behind CCDRAFOs effectiveness has been suggested to have ergogenic aid properties^2-5. This study’s purpose was to evaluate the effects of CCDRAFOs on collegiate athletes’ lower extremity biomechanics, specifically ankle and knee joint angles.