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Full-Text Articles in Medicine and Health Sciences
Acoustic Objective And Subjective Measurements Of Noise Levels In Various Places Of Worship And The Potential Consequences On The Auditory System, Celeste Thomas
Undergraduate Research Posters 2015
The purpose of this study is to record the objective and subjective measurements of noise levels in ten religious institutions of various faiths: Apostolic/Pentecostal, Baptist, Catholic, Muslim, Non-Denominational, and Seven-Day Adventist places of worship within the greater Cleveland area; in conjunction with the assessing the hearing sensitivity of the ministerial staff members who are most susceptible to prolonged noise exposure. The objective is to generate a statistical analysis of the objective acoustical measurements of primary church services of all participating religious institutions determine if the noise levels are loud enough to cause potential harm to the auditory system. The researcher …
Characterization Of The Detailed Interaction Interface Between T. Brucei Telomere Proteins Trf And Tif2, Jennifer Kungle, John Sabljic, Tia Nikova
Characterization Of The Detailed Interaction Interface Between T. Brucei Telomere Proteins Trf And Tif2, Jennifer Kungle, John Sabljic, Tia Nikova
Undergraduate Research Posters 2015
The protozoan parasite Trypanosoma brucei causes fatal African trypanosomiasis in humans and nagana in cattle. T. brucei switches its variant surface glycoproteins (VSGs) inside the mammalian host, evading the host immune response. VSGs are expressed monoallelically from subtelomeric expression sites, and telomere proteins regulate VSGs. We previously found that telomere protein TbTIF2 interacts with TbTRF (TTAGGG-repeat binding factor) and plays important roles in VSG switching regulation. TbTRF maintains the telomere terminal structure. TbTIF2 is essential for subtelomeric integrity and suppresses VSG switching by inhibiting subtelomeric gene conversion. Depletion of TbTIF2 decreases TbTRF protein level. We hypothesize that TbTRF-TbTIF2 interaction is …
Novel Regulation Of The Pro-Apoptotic Protein Puma In Response To Hypoxia, Mareem Ali, Brianna Boslett
Novel Regulation Of The Pro-Apoptotic Protein Puma In Response To Hypoxia, Mareem Ali, Brianna Boslett
Undergraduate Research Posters 2015
Ischemic injury in skeletal muscle caused by hypoxic (low oxygen) conditions occurs in response to vascular and musculoskeletal traumas, diseases and following reconstructive surgeries. Hypoxia induces apoptotic cell death. We have reported that the protein PUMA plays a critical role in the apoptosis of myoblasts in response to culture in differentiation media as well as exposure to DNA damaging chemotherapeutic agents. We have also determined that the transcription factor MyoD, known to control the differentiation process, also plays a role in these apoptotic processes by directly increasing the expression of PUMA mRNA. Herein, we report an increase in PUMA protein …
Assaying The Splicing Activity Of Novel Human Disease Variants Of U4atac Snrna, Maitri K. Patel, Rosemary C. Dietrich
Assaying The Splicing Activity Of Novel Human Disease Variants Of U4atac Snrna, Maitri K. Patel, Rosemary C. Dietrich
Undergraduate Research Posters 2015
In eukaryotes, pre-messenger RNA (pre-mRNA) splicing is an essential process in gene expression. Splicing is carried out by a dynamic multi-megadalton RNA-protein complex known as the spliceosome. Sequential transesterification reactions catalyzed by the spliceosome convert pre-mRNA to mRNA by removing the intervening sequences (introns) and joining the coding sequences (exons) together. Small nuclear RNAs (snRNAs) are essential splicing factors. Biallelic mutations of the human RNU4ATAC gene, which codes for U4atac snRNA, have been identified in patients diagnosed with Microcephalic Osteodysplastic Primordial Dwarfism type I (MOPD I). MOPD I is an autosomal recessive disorder characterized by extreme intrauterine growth retardation, multiple …
Dual Stimuli Response Frequency And Stimulus Choice Of The African Clawed Frog, Xenopus Laevis, When Presented With Two Stimuli, Mingo Rolince, Heidi Pignolet, Alexa Hoy
Dual Stimuli Response Frequency And Stimulus Choice Of The African Clawed Frog, Xenopus Laevis, When Presented With Two Stimuli, Mingo Rolince, Heidi Pignolet, Alexa Hoy
Undergraduate Research Posters 2015
This preliminary study examines responses of African Clawed Frogs to simultaneous presentation of two stimuli. Frogs were tested in a round arena with water 4 cm deep. Four stimulus rods driven via computer-controlled stepper motors were concealed in a screen suspended above the water. These rods could present a lateral line stimulus, a visual stimulus, or a combination of both. Overall, reactions and no reactions were evenly distributed--51.1% and 48.9%, respectively. Frogs responded more frequently to rostral than caudal stimuli (chi-squared 20.8, df=11, p < 0.04). Frogs reacted more to stimuli between -90° and 90°. Turn angle depended linearly on stimulus angle (e.g., Turn angle = 0.44 + 0.64 x Stimulus angle; pslope < 0.0001; R2adj = 69.5%). (The distributions of stimulus angles appear slightly skewed as often the same stimulus rod was retested after the frog responded and partially oriented towards it, prompting a second test with smaller angles.) Two stimuli did not elicit more responses than one stimuli (P=0.25). The frogs’ choice of stimulus depended primarily on stimulus proximity and angle, not stimulus type. When presented with two stimuli, the frog chose the nearer stimulus and the more rostral stimulus (p < 0.0001). The largest factor in predicting the frog’s choice of stimuli seems to be the linear distance from the stimuli to the frog.
Control Of Meiotic Cell Divisions In Presence Of Unrepaired Chromosome Breaks, Francisco Monge, Jesus Monge, Andrew Reville, Rima Sandhu
Control Of Meiotic Cell Divisions In Presence Of Unrepaired Chromosome Breaks, Francisco Monge, Jesus Monge, Andrew Reville, Rima Sandhu
Undergraduate Research Posters 2015
Chromosome miss-segregation during meiosis is a major factor contributing to birth defects as well as many genetic anomalies through the formation of aneuploid gametes, i.e. gametes with a deficit or surplus of one or several chromosomes. The synaptonemal complex (SC) is a major protein structure assembled with the synapsis of homologous chromosomes and is conserved from unicellular yeast to humans. One of its major roles during prophase I in meiosis is providing a structural framework for the maintenance of synapsis to facilitate the completion of reciprocal crossover events. Failure to form an effective SC or to experience crossover events leads …
Role In Recombination Of Genes That Control Meiotic Cell Divisions, Francisco Monge, Jesus Monge, Andrew Reville, Rima Sandhu
Role In Recombination Of Genes That Control Meiotic Cell Divisions, Francisco Monge, Jesus Monge, Andrew Reville, Rima Sandhu
Undergraduate Research Posters 2015
The production of gametes in Saccharomyces cerevisiae via meiosis is under strict regulatory control where proper segregation of homologous chromosomes into gametes requires physical linkage via crossovers. Cells that initiate meiotic recombination but do not process programmed double strand breaks into crossovers enter meiotic arrest. The main goal of the current project was whether overexpression of gene Y is sufficient to bypass the meiotic arrest in prophase I exhibited by dmc1 deletion and a zip1 mutant that carries an internal deletion. DMC1 is a recombinase that promotes homologous recombination. ZIP1 is a transverse filament protein of the synaptonemal complex (the …
Lead Optimization Of Tubulin Inhibitor For Cancer Treatment, Morgan Ashcraft
Lead Optimization Of Tubulin Inhibitor For Cancer Treatment, Morgan Ashcraft
Undergraduate Research Posters 2015
Tubulin-containing structures are important for many important cellular functions, including chromosome segregation during cell division, development and maintenance of cell shape, cell motility, and distribution of molecules on cell membranes. The rapid growth of cancer cells makes them very sensitive to the disruption of tubulin polymerization/depolymerization. Taxol (paclitaxel), a tubulin inhibitor approved by the FDA in 1992 for cancer treatment, is one of the most powerful chemotherapeutic agents. However, the low water solubility and drug resistance limits its clinical application. Various effort in drug discovery field focuses on more water soluble smaller molecular tubulin inhibitors. Our previous study led to …
Optimizing The Design And Potency Of Diterpenic Acid Derivatives To Improve Cell Membrane Permeability And Hsp27 Targeting Characteristics, Aicha Quamine
Undergraduate Research Posters 2015
Heat shock protein 27 (Hsp27) acts as a protective protein allowing it to play an integral role in aiding cancer cell resistance. Stress-induced Hsp 27 overexpression aids in the stabilization of partially denatured proteins to establish protein refolding resulting in thermotolerance, inhibition of apoptosis, cytoprotection, etc. As a result of rapid proliferation and general instability, cancer cells exhibit increased dependency on the support of Hsp 27 and it’s chaperone proteins, therefore generating an ideal target for anticancer therapy. Copalic acid, a clerodane diterpenoid, has already been confirmed in effective chaperone inhibition and antiproliferative synergistic effect. We hypothesize that by optimizing …
Mechanism Of Action By Which 5-Nidr Acts As A Therapeutic Agent Against Brain Cancer, Seol Kim, Jung-Suk Choi
Mechanism Of Action By Which 5-Nidr Acts As A Therapeutic Agent Against Brain Cancer, Seol Kim, Jung-Suk Choi
Undergraduate Research Posters 2015
Approximately 10,000 people in the United States are diagnosed annually with a brain tumor. In addition, the prognosis for brain cancer patients is poor as these cancers have low survival rates of less than 10%. One important chemotherapeutic agent used to treat brain cancer is temozolomide, an alkylating agent that causes cell death by damaging DNA. In this project, we tested the ability of a specific non-natural nucleoside developed in our lab, designated 5-NIdR, to increase the efficacy of temozolomide against brain cancer. Animal studies using xenograft mice were performed to evaluate the in vivo efficacy of this drug combination …
Nitrosylation Of S100a8/ A9 Protein Complex By Inducible Nitric Oxide Synthase, Kia Smith
Nitrosylation Of S100a8/ A9 Protein Complex By Inducible Nitric Oxide Synthase, Kia Smith
Undergraduate Research Posters 2015
How does the body fight infection? What causes inflammation? These are only a few questions that have been asked by many doctors across the globe. One thing that is known for certain about infection is that there is a particular sub-group of enzymes called NOS’s (eNOS, nNOS and iNOS) that produce Nitric Oxide (NO), a molecule radical capable of oxidizing proteins and alter their function. In our study we focus on inducible Nitric Oxide Synthase (iNOS). NOS’s are comprised of oxidase and reductase domains liked by Camodulin (CAM), a polypeptide linker. According to prior studies and SEM photographs, inducible Nitric …
Cell Surface Sialylation Status Of Monocytes And Macrophages, Henry Wang, Dan Wang
Cell Surface Sialylation Status Of Monocytes And Macrophages, Henry Wang, Dan Wang
Undergraduate Research Posters 2015
Sialic acids (SAs), a family of 9-carbon containing acidic monosaccharides, often terminate the glycan structures of cell surface glycoconjugates such as glycoproteins and glycolipids. The levels and linkages of sialic acids named as sialylation status vary as cell environment changes related to both physiological and pathological processes. Changes in sialylation of cell surface modulate cellular activity. SAs are highly involved in the immune system, however, the sialylation status related to individual immune cells and their activation state and functions are still unknown. In this study, we used a newly developed LC-MS/MS method to examine the cellular SA content during THP-1 …
Development Of A Gc-Ms Method For Investigation Mouse Plasma Amino Acid Levels And Their Significance To The Circadian Clock, Kylin Emhoff
Development Of A Gc-Ms Method For Investigation Mouse Plasma Amino Acid Levels And Their Significance To The Circadian Clock, Kylin Emhoff
Undergraduate Research Posters 2015
An extraction procedure and gas chromatography mass spectrometry (GC-MS) method was developed for quantitation of plasma amino acids. The experimental workflow included extraction of amino acids from plasma, followed by derivatization protocol for GC-MS compatibility. Automated Mass spectral Deconvolution and Identification System (AMDIS) and laboratory developed library was used for compound identification. Levels of plasma amino acids were calculated based on one point calibration with non-physiological amino acid L-norvaline as internal standard. The assay was applied to obtain and monitor levels of plasma amino acids to study the effect of feeding restriction on the circadian clock in mice. The circadian …
Balance Training Application Of A Systematic Framework For Clinical Decision Making In Therapeutic Gaming For Older Adults, Brian Boccieri
Balance Training Application Of A Systematic Framework For Clinical Decision Making In Therapeutic Gaming For Older Adults, Brian Boccieri
Undergraduate Research Posters 2015
Falling is a major health concern for older adults. Balance is crucial in order to prevent falls. For balance to be functional an individual must be able to maintain balance while focusing on other tasks. For example, an individual must focus on more than just staying upright during walking while drinking a mug of coffee, or during standing while washing dishes. There are a countless number of daily activities that challenge balance. One of the problems with current clinical balance rehabilitation is that the training is often completed using isolated exercises that do not include the various other cognitive and …
Safe Movement Practices By Stnas For Residents In Nursing Homes, Christine Fortuna
Safe Movement Practices By Stnas For Residents In Nursing Homes, Christine Fortuna
Undergraduate Research Posters 2015
Previous research reports that with compliance, safe movement programs and policies play a large roll in reducing worker injury and safe patient handling. The purpose for our research is to better understand the daily safe movement practices of State Tested Nursing Assistants as it relates to the safe handling and transferring of patients. We used Qualtric software to electronically survey 14 STNAs from Jenning’s Center for Older Adults Upper Level Neighborhood. The survey consisted of 7 forced choice questions and 19 open ended or follow up questions. The scope of our research covers the complexities of the daily tasks of …
Statistical Analysis Of Dasi Questionnaire And Modeling The Prediction Of Heart Failure Risk In Patients, Christian Negron
Statistical Analysis Of Dasi Questionnaire And Modeling The Prediction Of Heart Failure Risk In Patients, Christian Negron
Undergraduate Research Posters 2015
9,880 patients were asked to complete the DASI questionnaire along with other questions to assess the predictability of heart failure risk. In this paper we attempt to reduce the amount of questions asked by hierarchical clustering of the question responses to determine if there is a change in the predictability of heart failure risk in patients. The data was modeled using Cox hazards multiple regression and validated through ROC and AUC. Our validation models show there is no difference between the usage of 12 and 6 DASI questions, therefore improving the simplicity of the questionnaire. Abbreviations: DASI, Duke Activity Status …
Dynamics Of An Optically Trapped Particle, Flaherty Justin
Dynamics Of An Optically Trapped Particle, Flaherty Justin
Undergraduate Research Posters 2015
Particles trapped in a laser experience a linear restoring force that keeps them centered in the trap and will undergo restricted Brownian motion. The Brownian motion causes a change in the scattered laser light. The scattered light is projected onto a Quadrant Photodiode and can be used to obtain the Mean Squared Displacement of the particle, as well as the linear spring constant of the laser trap. The spring constant can be used to obtain the force applied by the laser trap, which is in the realm of piconewtons.
Ciliary Mechanosensation In Mdck Cells, Muhammad Tayeh
Ciliary Mechanosensation In Mdck Cells, Muhammad Tayeh
Undergraduate Research Posters 2015
Cilia are microscopic structures that extend from the surface of mammalian cells. Cilia can be categorized into two groups, primary cilia (non-motile) and motile cilia. Cilia are composed of tubulin subunits (microtubules) and covered by a plasma membrane. The physiological role of motile cilia has been very well documented, but the function of primary cilia remains largely unknown. It has been shown that primary cilia allow cells to sense and respond to mechanical stimuli. The ability for a cell to respond to mechanical stimuli is crucial for maintaining processes such as homeostasis. It has also been shown that defects in …
Developing Affordable Wet-Sample Electron Microscopy Integrated With A Temperature Controlled Sample Holder, Dan Terrano
Developing Affordable Wet-Sample Electron Microscopy Integrated With A Temperature Controlled Sample Holder, Dan Terrano
Undergraduate Research Posters 2015
Scanning electron microscopy (SEM) is widely used to analyze the size, shape and composition of material systems. However, using this tool for analyzing systems such as particles suspended in solution, requires drastic sample alterations, such as precipitation and fixation. Besides altering their environment, this exposes the particles to the harsh conditions within an electron microscope, such as high vacuum and electron beam exposure. To this end, the first goal of this study was to develop methodologies for imaging wet samples using electron microscopy. This is realized by creating a sandwich structure containing the solution of interest between a partially electron …
Deducing Shape Of Anisotropic Particles In Solution From Light Scattering: Spindles And Nanorods, Ilona Tsuper, Dan Terrano
Deducing Shape Of Anisotropic Particles In Solution From Light Scattering: Spindles And Nanorods, Ilona Tsuper, Dan Terrano
Undergraduate Research Posters 2015
Depolarized Dynamic light scattering (DDLS) enables to measure in situ rotational and translational diffusion of nanoparticles suspended in solution. Their size, shape, diffusion, and intermolecular interactions can be interred then from DDLS data using various models of diffusion. Incorporating DDLS to analyze the dimensions of easily imaged elongated particles, such as Iron (III) oxyhydroxide Spindles (FeOOH) and gold coated Nanorods, will allow a deeper understanding between rotational/translational diffusion and size distribution of hard-to-image anisotropic wet systems such as micelles, microgels, and protein complexes. The emphasis of this study was to look at the aged FeOOH Spindle sample, and explore the …
The Effect Of Depression Symptoms On The Cardiac Autonomic Response To Positive Mood Induction, Elizabeth Golias, Khadeja Najjar, Brock Bodenbender
The Effect Of Depression Symptoms On The Cardiac Autonomic Response To Positive Mood Induction, Elizabeth Golias, Khadeja Najjar, Brock Bodenbender
Undergraduate Research Posters 2015
Depression is characterized by a reduced capacity to experience pleasure (hedonic capacity). A growing literature suggests that hedonic capacity is supported by the sympathetic (SNS) and parasympathetic (PNS) branches of the autonomic nervous system. Both branches may work in a reciprocal fashion, or in tandem, reflecting co-activation of the SNS and PNS. While reduced PNS and increased SNS activity are associated with happy states among healthy individuals, preliminary findings suggest that depressed persons evidence blunted physiologic responses across a variety of emotion inducing stimuli. Much of this work, however, has examined PNS and SNS activity separately, and never with respect …
Autonomic Nervous System Response To Interpersonal Exclusion In Borderline Personality Disorder, Ilona Ponomariova, Brock Bodenbender, Khadeja Najjar, Elizabeth Golias
Autonomic Nervous System Response To Interpersonal Exclusion In Borderline Personality Disorder, Ilona Ponomariova, Brock Bodenbender, Khadeja Najjar, Elizabeth Golias
Undergraduate Research Posters 2015
Intense emotional reactions to interpersonal rejection reflect the core of Borderline Personality Disorder (BPD). These reactions supported by the autonomic nervous system (ANS), which has been linked to neural regions that undergird emotional experience and regulation that are affected among individuals with BPD. Despite such links, relatively few studies have examined ANS functioning among BPD populations. The few studies that have primarily focused on the independent activity of the two sympathetic (SNS) and parasympathetic (PNS) ANS branches during resting states or in response to emotion evocative films, rather than to interpersonal rejection. The present study overcomes the above noted gaps …
Cultural Differences In Coping And Depression Between Individuals Of Middle-Eastern And Non-Arab Backgrounds, Khadeja Najjar
Cultural Differences In Coping And Depression Between Individuals Of Middle-Eastern And Non-Arab Backgrounds, Khadeja Najjar
Undergraduate Research Posters 2015
The Middle Eastern (Arab) demographic is a growing, yet neglected cultural group in mental health research. While Arabs are more predisposed to depression than other ethnic groups in US, little is known about mechanisms that account for this risk. One set of mechanisms may be the use of ineffective (maladaptive) coping or insufficient use of effective (adaptive) coping responses, which are robust predictors of depression in US samples, but virtually unexamined in Arabs. Further, the effect of a coping is influenced by culture, which, for Arabs, may change as a function of acculturation. Thus, the present study aimed to examine …
Enhancement Of Solar Energy Conversion In Bio-Derived Cells Via Side Selective Modification Of Photosystem I, Uchechukwu Obiako, Evan Gizzie
Enhancement Of Solar Energy Conversion In Bio-Derived Cells Via Side Selective Modification Of Photosystem I, Uchechukwu Obiako, Evan Gizzie
Undergraduate Research Posters 2015
Deleterious effects of some methods used to harness energy from the environment today have garnered the exploration of safer and more reliable options, specifically solar energy conversion. Current solar cell technology has yielded quantum efficiencies commonly in the range of 10-20% but is limited by extensive processing methods, high cost, and need for rare materials. However, bio-derived solar cells containing Photosystem I (PSI) address these problems as PSI is highly abundant, very efficient, and low-cost. PSI acts as a biomolecular photodiode through rapid photoexcited charge separation, making it very promising for use as an integral element in solar cells. To …
Designing Tuftsin Conjugate For Directing Antimicrobial Ionophores To Macrophages, Sokhna Seck, Zeenat Razvi
Designing Tuftsin Conjugate For Directing Antimicrobial Ionophores To Macrophages, Sokhna Seck, Zeenat Razvi
Undergraduate Research Posters 2015
For all microorganisms, acquisition of metal ions is essential for survival in the environment or their infected host. Metal ions are required in many biological processes as cofactors for proteins or structural elements for enzymes. These ions play a role in chemotaxis, phosphorylation, transport of sugars and proteins, and initiation of DNA replication, among other things. It is critical for bacteria to ensure that metal uptake and availability meet its physiological needs; too little can impede these important biological processes, while too much can be toxic leading to radical formation which can cause damage to proteins and cell structures (Porcheron, …
Feasibility And Effects Of Accelerometer Based Feedback On Paretic Upper Extremity Amount Of Use In The Home Setting In Subjects Chronic Post-Stroke, Nathan Pohl, Amber Kuehn, Mishgan Abdullah
Feasibility And Effects Of Accelerometer Based Feedback On Paretic Upper Extremity Amount Of Use In The Home Setting In Subjects Chronic Post-Stroke, Nathan Pohl, Amber Kuehn, Mishgan Abdullah
Undergraduate Research Posters 2015
Purpose : to (1) evaluate the feasibility of using accelerometers in the home to quantify how much subjects chronic post-stroke (PS) use their upper extremities (UE), (2) measure differences between amount of UE movement in subjects PS and a healthy control group (HC), (3) determine the effects of accelerometer based feedback on paretic UE use in subjects PS, and (4) determine if those effects are retained over time. Methods : Six subjects PS wore accelerometers for 3 weeks with two feedback sessions given during week two. Seven HC subjects wore accelerometers for one week. Accelerometer based outcome measures included relative …
Effects Of Accelerometer Based Feedback On Clinical Measures And Paretic Upper Extremity Amount Of Use In Subjects Chronic Post-Stroke, Amber Kuehn, Nathan Pohl, Mishgan Abdullah
Effects Of Accelerometer Based Feedback On Clinical Measures And Paretic Upper Extremity Amount Of Use In Subjects Chronic Post-Stroke, Amber Kuehn, Nathan Pohl, Mishgan Abdullah
Undergraduate Research Posters 2015
Purpose/Hypothesis: To determine the effects of accelerometer based feedback on clinical measures of paretic upper extremity (UE) recovery in people post-stroke and examine the relationship between these changes and paretic UE amount of use (AOU) measured by an accelerometer. Subjects: 7 people chronic post-stroke (5 males, 2 females; aged 62.03 ± 11.33 years) with an Upper Extremity Fugl-Meyer score range of 10-63 were included for this poster. Materials/Methods: Subjects wore wrist accelerometers for 3 weeks in the home. Clinical measures (Motor Activity Log, Stroke Impact Scale, Chedoke Arm and Hand Activity Inventory, and the ABILHAND) were assessed weekly. Data analysis …
Effect Of Accelerometer Based Feedback On Paretic Upper Extremity Amount Of Use And Quality Of Movement: A Case Study, Mishgan Abdullah, Nathan Pohl, Amber Kuehn
Effect Of Accelerometer Based Feedback On Paretic Upper Extremity Amount Of Use And Quality Of Movement: A Case Study, Mishgan Abdullah, Nathan Pohl, Amber Kuehn
Undergraduate Research Posters 2015
Purpose/Hypothesis: To determine the effects of accelerometer based feedback on clinical measures of paretic upper extremity (UE) recovery in people post-stroke and examine the relationship between these changes and paretic UE amount of use (AOU) measured by an accelerometer. Subjects: 7 people chronic post-stroke (5 males, 2 females; aged 62.03 ± 11.33 years) with an Upper Extremity Fugl-Meyer score range of 10-63 were included for this poster. Materials/Methods: Subjects wore wrist accelerometers for 3 weeks in the home. Clinical measures (Motor Activity Log, Stroke Impact Scale, Chedoke Arm and Hand Activity Inventory, and the ABILHAND) were assessed weekly. Data analysis …
Distribution Of Sphaeriid Clams In Lake Erie Twenty-Five Years After Invasion Of Dreissena, Michael Keller
Distribution Of Sphaeriid Clams In Lake Erie Twenty-Five Years After Invasion Of Dreissena, Michael Keller
Undergraduate Research Posters 2015
Clams in the family Sphaeriidae are widespread native mollusk species that are often overlooked. The distribution of these organisms in Lake Erie has not been examined in the 25 years since the initial invasion of the zebra mussel, Dreissena polymorpha. Carr and Hiltunen identified 10 species of Sphaeriidae in Western Lake Erie in 1961, of which Pisidium casertanum, P. compressum, P. nitidum, Sphaerium corneum, and S. striatinum and Musculium transversum, contributed 89.7% of all fingernail and pea clams sampled and were considered common. Four other species were reported as rare. Our research examines whether the distribution of Sphaeriid clams in …
Investigating Rhoptry Gene Conservation Between Plasmodium Yoelii And Plasmodium Falciparum Using The Polymerase Chain Reaction For Dna Amplification, Brooke Burkhalter
Investigating Rhoptry Gene Conservation Between Plasmodium Yoelii And Plasmodium Falciparum Using The Polymerase Chain Reaction For Dna Amplification, Brooke Burkhalter
Undergraduate Research Posters 2015
In order to obtain a tangible basis for vaccine targets, it is crucial to understand the role of proteins at the site of invasion. In previous study, 27 novel rhoptry proteins were identified by MudPIT analysis and immunoelectron microscopy. In this investigation, the conservation of rhoptry genes between Plasmodium yoelii and Plasmodium falciparum was assessed. From the previously identified rhoptry genes, 14 were investigated with the orthologues/paralogues of the Plasmodium falciparum, Plasmodium yoelii, Plasmodium chabaudi, and Plasmodium berghei. Also, primers designed for the 14 Plasmodium yoelli rhoptry genes were used to test DNA amplification with the PCR. Amplification of Plasmodium …