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Inhibitory Role Of Sphingosine 1-Phosphate Receptor 2 In Macrophage Recruitment During Inflammation, Jason Michaud, Timothy Hla, Dong-Soon Im
Inhibitory Role Of Sphingosine 1-Phosphate Receptor 2 In Macrophage Recruitment During Inflammation, Jason Michaud, Timothy Hla, Dong-Soon Im
UCHC Articles - Research
Macrophage recruitment to sites of inflammation is an essential step in host defense. However, the mechanisms preventing excessive accumulation of macrophages remain relatively unknown. The lysophospholipid sphingosine 1-phosphate (S1P) promotes T and B cell egress from lymphoid organs by acting on S1P receptor 1 (S1P1R). More recently, S1P5R was shown to regulate NK cell mobilization during inflammation, raising the possibility that S1P regulates the trafficking of other leukocyte lineages. In this study, we show that S1P2R inhibits macrophage migration in vitro and that S1P2R-deficient mice have enhanced macrophage recruitment during thioglycollate peritonitis. …