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Autoradiographic Localization Of [3h]-Nisoxetine Binding Sites In The Cns Of Male And Female Japanese Quail, Shannon E. Eaton, James R. Pauly, Deann M. Hopkins, Chana K. Akins

Pharmaceutical Sciences Faculty Publications

Background

In the central nervous system of mammals, transporters localized on the presynaptic nerve terminals regulate the reuptake of neurotransmitters. These transporters are selective for a specific neurotransmitter such as dopamine (DA) and norepinephrine (NE). Specifically in the synapse, the dopamine transporter (DAT) reuptakes DA and the norepinephrine transporter (NET) reuptakes NE. However previous research has found that avian species do not have a gene for DAT, and therefore, birds may be using the NET to clear both NE and DA from the synapse. The current study aimed to extend this finding by localizing NET expression in male and female …