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Full-Text Articles in Medicine and Health Sciences
Visualizing Phytochemical-Protein Interaction Networks: Momordica Charantia And Cancer, Yumi L. Briones, Alexander T. Young, Fabian M. Dayrit, Armando Jerome De Jesus, Nina Rosario L. Rojas
Visualizing Phytochemical-Protein Interaction Networks: Momordica Charantia And Cancer, Yumi L. Briones, Alexander T. Young, Fabian M. Dayrit, Armando Jerome De Jesus, Nina Rosario L. Rojas
Chemistry Faculty Publications
The in silico study of medicinal plants is a rapidly growing field. Techniques such as reverse screening and network pharmacology are used to study the complex cellular action of medicinal plants against disease. However, it is difficult to produce a meaningful visualization of phytochemical-protein interactions (PCPIs) in the cell. This study introduces a novel workflow combining various tools to visualize a PCPI network for a medicinal plant against a disease. The five steps are 1) phytochemical compilation, 2) reverse screening, 3) network building, 4) network visualization, and 5) evaluation. The output is a PCPI network that encodes multiple dimensions of …
Metabolic Outcomes Of Anaplerotic Dodecanedioic Acid Supplementation In Very Long Chain Acyl-Coa Dehydrogenase (Vlcad) Deficient Fibroblasts, Igor Radzikh, Erica Fatica, Jillian Kodger, Rohan Shah, Ryan Pearce, Yana Sandlers
Metabolic Outcomes Of Anaplerotic Dodecanedioic Acid Supplementation In Very Long Chain Acyl-Coa Dehydrogenase (Vlcad) Deficient Fibroblasts, Igor Radzikh, Erica Fatica, Jillian Kodger, Rohan Shah, Ryan Pearce, Yana Sandlers
Chemistry Faculty Publications
Very long-chain acyl-CoA dehydrogenase deficiency (VLCADD, OMIM 609575) is associated with energy deficiency and mitochondrial dysfunction and may lead to rhabdomyolysis and cardiomyopathy. Under physiological conditions, there is a fine balance between the utilization of different carbon nutrients to maintain the Krebs cycle. The maintenance of steady pools of Krebs cycle intermediates is critical for mitochondrial energy homeostasis especially in high-energy demanding organs such as muscle and heart. Even-chain dicarboxylic acids are established as alternative energy carbon sources that replenish the Krebs cycle by bypassing a defective β-oxidation pathway. Despite this, even-chain dicarboxylic acids are eliminated in the urine of …