Medicine and Health Sciences Commons^™

The Fkbp52 Cochaperone Acts In Synergy With Β-Catenin To Potentiate Androgen Receptor Signaling, Cheryl Samaniego, Ji Ho Suh, Arundhati Chattopadhyay, Karen Olivares, Naihsuan Guy, Jeffrey C. Sivils, Prasenjit Dey, Fumiak Yumoto, Robert J. Fletterick, Anders M. Strom, Jan-Åke Gustafsson, Paul Webb, Marc B. Cox

Biology Publications

FKBP52 and β-catenin have emerged in recent years as attractive targets for prostate cancer treatment. β-catenin interacts directly with the androgen receptor (AR) and has been characterized as a co-activator of AR-mediated transcription. FKBP52 is a positive regulator of AR in cellular and whole animal models and is required for the development of androgendependent tissues. We previously characterized an AR inhibitor termed MJC13 that putatively targets the AR BF3 surface to specifically inhibit FKBP52-regulated AR signaling. Predictive modeling suggests that β-catenin interacts with the AR hormone binding domain on a surface that overlaps with BF3. Here we demonstrate that FKBP52 …