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Study Of Two Human Myotubularin Homologs (Atmtm1 And Atmtm2) In Arabidopsis, Yang Zhao

School of Biological Sciences: Dissertations, Theses, and Student Research

Phosphatidylinositol 5 phosphate is appearing to play an important role in signal transduction as lipid second messenger. The synthesis of this lipid signal is mainly conducted by a group of phosphatase called myotubularins (MTM) which can dephosphorylate on the 3’s position of Phosphatidylinositol (3, 5) bi-phosphate. Mutations in active myotubularins lead to severe diseases in human. However, this essential family has been scarcely studied in plants. Recently, two myotubularins (AtMTM1 and AtMTM2) have been identified as the homologs of human MTM Related protein 2 (MTMR2) in Arabidopsis. While some evidence has been provided to suggest the function of AtMTM1, …