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School of Veterinary and Biomedical Sciences: Dissertations, Theses, and Student Research
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Host Cell Responses To Zika Virus Infection, Bikash R. Sahoo
Host Cell Responses To Zika Virus Infection, Bikash R. Sahoo
School of Veterinary and Biomedical Sciences: Dissertations, Theses, and Student Research
The re-emergence of Zika virus (ZIKV) in 2015 as a significant human pathogen causing neurological diseases in infants as well as adults is a serious global health concern. A clear understanding of the mechanisms involved in ZIKV replication in infected host cells as well as the host responses to virus infection are keys to the development of therapeutic strategies against ZIKV. Studies conducted in this dissertation demonstrate that ZIKV infection induces the activation of mTOR signaling cascade that promotes viral protein accumulation and infectious progeny production. While both mTORC1 and mTORC2 are essential for ZIKV replication, the observation that depletion …