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University of Nebraska - Lincoln
Department of Animal Science: Dissertations, Theses, and Student Research
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The Effects Of Omega-3 Pufa Infusions During Late Gestation On Developmental Pathologies In The Intrauterine Growth Restricted Fetus, Taylor Lacey
Department of Animal Science: Dissertations, Theses, and Student Research
Low birthweight due to intrauterine growth restriction is associated with metabolic disorders after birth. Our 1st study assessed deficits in skeletal muscle glucose metabolism and pancreatic β cell function in IUGR fetal sheep. We aimed to evaluate the effectiveness of daily intravenous infusions of the anti-inflammatory ω-3 polyunsaturated fatty acid (PUFA), eicosapentaenoic acid (EPA), as a means of improving deficits previously observed in the IUGR fetus by targeting fetal systemic inflammation. The presence of systemic inflammation in IUGR fetuses was evident by increased total circulating populations of total leukocytes, lymphocytes, and monocytes. However, these were …