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Prognostic Value Of Ishak Fibrosis Stage: Findings From The Halt-C Trial, Herbert L. Bonkovsky
Prognostic Value Of Ishak Fibrosis Stage: Findings From The Halt-C Trial, Herbert L. Bonkovsky
UCHC Articles - Research
Background and Aims
Studies of the prognostic value of Ishak fibrosis stage are lacking. We utilized multi-year follow-up of the Hepatitis C Antiviral Long Term Treatment Against Cirrhosis (HALT-C) Trial to determine whether individual Ishak fibrosis stages predicted clinical outcomes in patients with chronic hepatitis C.
Methods
Baseline liver biopsies from 1,050 patients with compensated chronic hepatitis C who had failed combination peginterferon and ribavirin were reviewed by a panel of expert hepatopathologists. Fibrosis was staged with the Ishak scale (ranging from 0=no fibrosis to 6=cirrhosis). Biopsy fragmentation and length as well as number of portal tracts were recorded. We …