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Touro College and University System
Alzheimer disease; immunotherapy; single-chain antibodies; amyloid; adeno-associated virus; cerebral hemorrhage
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Full-Text Articles in Medicine and Health Sciences
Anti-Amyloid-Β Single-Chain Antibody Brain Delivery Via Aav Reduces Amyloid Load But May Increase Cerebral Hemorrhages In An Alzheimer's Disease Mouse Model, Jinghong Kou, Hong-Duck Kim, Hiroaki Taguchi, Sudhir Paul, Selvarangan Ponnazhagan, Ken-Ichiro Fukuchi
Anti-Amyloid-Β Single-Chain Antibody Brain Delivery Via Aav Reduces Amyloid Load But May Increase Cerebral Hemorrhages In An Alzheimer's Disease Mouse Model, Jinghong Kou, Hong-Duck Kim, Hiroaki Taguchi, Sudhir Paul, Selvarangan Ponnazhagan, Ken-Ichiro Fukuchi
NYMC Faculty Publications
Accumulation of amyloid-β protein (Aβ) in the brain is thought to be a causal event in Alzheimer's disease (AD). Immunotherapy targeting Aβ holds great promise for reducing Aβ in the brain. Here, we evaluated the efficacy and safety of anti-Aβ single-chain antibody (scFv59) delivery via recombinant adeno-associated virus (rAAV) on reducing Aβ deposits in an AD mouse model (TgAβPPswe/PS1dE9). First, delivery of scFv59 to the brain was optimized by injecting rAAV serotypes 1, 2, and 5 into the right lateral ventricle. Symmetrical high expression of scFv59 was found throughout the hippocampus and partly in the neocortex in both hemispheres via …