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Full-Text Articles in Medicine and Health Sciences
Genetic And Cellular Studies Highlight That A Disintegrin And Metalloproteinase 19 Is A Protective Biomarker In Human Prostate Cancer, Gerard F. Hoyne, Caoline Rudnicka, Qing-Xiang Sang, Mark Roycik, Sarah Howarth, Peter Leedman, Markus Schlaich, Patrick Candy, Vance Matthews
Genetic And Cellular Studies Highlight That A Disintegrin And Metalloproteinase 19 Is A Protective Biomarker In Human Prostate Cancer, Gerard F. Hoyne, Caoline Rudnicka, Qing-Xiang Sang, Mark Roycik, Sarah Howarth, Peter Leedman, Markus Schlaich, Patrick Candy, Vance Matthews
Health Sciences Papers and Journal Articles
Background: Prostate cancer is the second most frequently diagnosed cancer in men worldwide. Current treatments include surgery, androgen ablation and radiation. Introduction of more targeted therapies in prostate cancer, based on a detailed knowledge of the signalling pathways, aims to reduce side effects, leading to better clinical outcomes for the patient. ADAM19 (A Disintegrin And Metalloproteinase 19) is a transmembrane and soluble protein which can regulate cell phenotype through cell adhesion and proteolysis. ADAM19 has been positively associated with numerous diseases, but has not been shown to be a tumor suppressor in the pathogenesis of any human cancers. Our group …