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Perinatal Hypoxic-Ischemic Encephalopathy And Neuroprotective Peptide Therapies: A Case For Cationic Arginine-Rich Peptides (Carps), Adam B. Edwards, Ryan S. Anderton, Neville W. Knuckey, Bruno P. Meloni

Health Sciences Papers and Journal Articles

Perinatal hypoxic-ischemic encephalopathy (HIE) is the leading cause of mortality and morbidity in neonates, with survivors suffering significant neurological sequelae including cerebral palsy, epilepsy, intellectual disability and autism spectrum disorders. While hypothermia is used clinically to reduce neurological injury following HIE, it is only used for term infants (>36 weeks gestation) in tertiary hospitals and improves outcomes in only 30% of patients. For these reasons, a more effective and easily administrable pharmacological therapeutic agent, that can be used in combination with hypothermia or alone when hypothermia cannot be applied, is urgently needed to treat pre-term (_36 weeks gestation) and …