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Articles 1 - 7 of 7
Full-Text Articles in Medicine and Health Sciences
Knowledge And Behaviors Surrounding A Gluten-Free Diet Between Medically And Self-Diagnosed Individuals, Sara Andrea Quinteros-Fernandez
Knowledge And Behaviors Surrounding A Gluten-Free Diet Between Medically And Self-Diagnosed Individuals, Sara Andrea Quinteros-Fernandez
Theses - ALL
Objective: Gluten, a protein found in wheat, rye and barley has been linked to the inflammatory response of the GI tract in individuals with Celiac Disease, non-celiac gluten sensitivity, and in some cases irritable bowel syndrome (IBS). Several factors have contributed to the increase in these gluten-related disorders in recent years, including improved medical diagnosis, public awareness of the disease, changes in the composition of wheat due to modern agricultural technologies and perceived health benefits from following a gluten-free diet. The purpose of this research was to examine the knowledge, behaviors and adherence to a gluten-free diet by individuals with …
The Use Of Shape Memory Polymers As A Tool To Study Human Fibrosarcoma And Murine Mesenchymal Stem Cell Migration, Justin N. Elkhechen
The Use Of Shape Memory Polymers As A Tool To Study Human Fibrosarcoma And Murine Mesenchymal Stem Cell Migration, Justin N. Elkhechen
Honors Capstone Projects - All
Shape memory polymers (SMPs) are a class of “smart” materials that can transform between two distinct conformations through external stimuli, such as heat or electricity. Their usage in bioengineering has led to a promising field of research that lies at the interface of cell and mechanobiology, potentially providing insight into cancer therapies and tissue development—two processes that exist in dynamic environments in vivo. The present work involves creating new, shape changing, scaffolds for studies to analyze cell migration upon changes to the environmental topography. Specifically, this Capstone has been primarily focused on the development of a “half and half” fibrous …
Characterization Of Ghrelin O-Acyltransferase Active Site, Leslie Patton
Characterization Of Ghrelin O-Acyltransferase Active Site, Leslie Patton
Honors Capstone Projects - All
Ghrelin, first discovered in 1999, is a 28-amino acid peptide hormone involved in the regulation of appetite, insulin secretion and sensitivity, and many neurological effects such as learning, memory, and depression.1-6 Ghrelin has been identified to have a unique posttranslational octanoylation carried out by the enzyme ghrelin O-acyltransferase (GOAT). This distinctive modification is a point of interest in studying GOAT whereby blocking the acylation of the ghrelin could potentially halt the activity of the peptide hormone and provide a means of treating obesity, diabetes, and other diseases affected by ghrelin levels. The duration of my project involved working …
Estrodial Effects On Age-Related Shifts In Learning And Memory: A Multiple Memory Systems Approach, Luis Castelan
Estrodial Effects On Age-Related Shifts In Learning And Memory: A Multiple Memory Systems Approach, Luis Castelan
Honors Capstone Projects - All
Many findings from our lab and others suggest that circulating estrogens as well as estrogen replacement after ovariectomy influence cognitive performance. Young female rats trained during proestrus, when estrogens are high, or with acute estradiol (E2) administration after ovariectomy perform better on the hippocampus-sensitive place task but worse on the striatum-sensitive response task (Korol et al., 2004; Korol and Kolo, 2002). Behavioral neuroscience studies tend to use male rodent models to avoid the complexities of the female reproductive cycle, producing a gap in our knowledge about neural mechanisms of learning and memory in females. As a consequence, age-related effects of …
The Incidence Of Chagas Coinfections Amongst Acute Dengue Patients In Machala, Ecuador, Elizabeth A. Mcmahon
The Incidence Of Chagas Coinfections Amongst Acute Dengue Patients In Machala, Ecuador, Elizabeth A. Mcmahon
Honors Capstone Projects - All
Dengue fever is a febrile illness found throughout the tropics that, in severe cases, can be deadly. The most rapidly spreading of any mosquito-borne disease, dengue is re-emerging as an illness of great concern in Latin America and around the globe. The CDC estimates that as many as 400 million cases of dengue occur each year. The pathogenesis of dengue virus is complicated and acts through modulation of the host immune system. Dengue polarizes the immune system balance of T helper 1 (Th1) and T helper 2 (Th2) cells towards a Th1 inflammatory response. Parasitic infections have also been shown …
Differential Activation Of Microglia In An In Vitro Model Of Intracerebral Hemorrhage, Bhakti Patel
Differential Activation Of Microglia In An In Vitro Model Of Intracerebral Hemorrhage, Bhakti Patel
Honors Capstone Projects - All
An in vitro model of intracerebral hemorrhage was established to examine the protective versus cytotoxic roles of microglia in the context of mild versus severe injury. Co-cultures of microglia, astrocytes, and granule neurons were prepared from the cerebellar cortex of neonatal rats, and grown in standard medium containing fetal bovine serum or, in some cases, a serum-free chemically defined medium. To mimic hemorrhagic stroke, co-cultures grown for 7-8 days in vitro were challenged with two different concentrations of the toxic blood product hemin, corresponding to a mild versus a severe brain bleed. Immunocyto-chemical, real-time RT-PCR, iron deposition, and cell survival …
Maternal Obesity And Incidence Of Depression, Caroline A. Habjan
Maternal Obesity And Incidence Of Depression, Caroline A. Habjan
Honors Capstone Projects - All
Obesity is a national epidemic in the United States, which both directly and indirectly affects the social productivity of individuals, the American macro economy and individuals’ personal health and well being. Depression often interferes with an individual’s ability to work, sleep, study, eat, and enjoy life. A maternal state of both obesity and depression may cause serious adverse medical conditions in the mother’s child. Taking steps to treat depression and obesity are critical in the construct of modern medicine. This project yields results that have the potential to make treatment options better tailored, more efficient, effective and economically-sound for the …