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Full-Text Articles in Medicine and Health Sciences
Investigation Of The Effects Of Prenatal Drug Exposure On Astrocyte-Mediated Synaptogenic Signaling, Taylor Christian Boggess
Investigation Of The Effects Of Prenatal Drug Exposure On Astrocyte-Mediated Synaptogenic Signaling, Taylor Christian Boggess
Theses, Dissertations and Capstones
One of the most significant outcomes of the rise in rates of opioid abuse in the United States has been a dramatic increase in the incidence of neonatal abstinence syndrome (NAS), the clinical diagnosis for the collection of withdrawal-like signs and symptoms commonly observed in the newborns of mothers who abused certain drugs, such as opioids, during pregnancy. While a great deal of research has investigated the short-term symptoms and potential treatments for NAS, including my own studies to identify emerging trends among a local population of NAS patients, there remains a critical need to investigate the long-term effects of …
From Crib To Bench: Understanding Neonatal Opioid Withdrawal Syndrome (Nows) Using A Novel Rodent Model, Sarah Stevens
From Crib To Bench: Understanding Neonatal Opioid Withdrawal Syndrome (Nows) Using A Novel Rodent Model, Sarah Stevens
Theses, Dissertations and Capstones
As the opioid epidemic continues to grow, opioid use among pregnant women is increasing significantly. This has led to a steady rise in the number of infants born with neonatal opioid withdrawal syndrome (NOWS). Although short-term withdrawal symptoms associated with NOWS are well characterized, there are many gaps in our understanding of the short and long-term effects of prenatal opioid exposure. In CHAPTER 1, we describe the clinical presentation, associated neurodevelopmental challenges, and current treatments of NOWS. Our current understanding of the neuropathology of NOWS is limited, and therefore further research is needed. However, current animal models are limited by …