Medicine and Health Sciences Commons^™

Systematic Analysis Of Whole Exome Sequencing Determines Ret G691s Polymorphism As Germline Variant In Melanoma, Brent J. Smith Jr, Jennifer D. Hintzsche, Carol M. Amato, Aik-Choon Tan, Keith R. Wells, Allison J. Applegate, Rita T. Gonzalez, Jodie R. Barr, William A. Robinson

Marshall Journal of Medicine

Abstract

The RET proto-oncogene encodes a receptor tyrosine kinase that is activated by glial cell derived neutrotrophic factor (GDNF). Previous studies have found that a single nucleotide polymorphism (SNP), RETp (G691S), in the juxtamembrane domain enhances the signaling pathway and promotes tumor growth by GDNF in pancreatic and thyroid cancer in addition to melanoma. It is uncertain however whether this SNP is a germline variant or somatic mutation. A prior study reported that the RETp variant was a germline SNP in desmoplastic and non-desmoplastic melanomas. In the present study, we examined both melanoma tissue samples and matching peripheral blood DNA …

Tenofovir Induced Nephrotoxicity: A Mechanistic Study, Rachel A. Murphy

Theses, Dissertations and Capstones

Tenofovir (TFV) is a reverse transcriptase inhibitor that is approved by the United States Food and Drug Administration (FDA) to treat HIV and chronic Hepatitis B. It has a long half-life, allowing for once a day dosing and is effective in treatment of both naive and experienced patients. It is administered orally as tenofovir disoproxil fumarate (TDF) and is deesterified in plasma to the active drug TFV. However, renal impairment is associated with its use; TFV can induce decreased glomerular filtration rate (GFR) and free calcitriol, renal failure, and Fanconi Syndrome. The exact mechanism of toxicity currently remains unknown, largely …

The Effects Of Flexor Pronator Mass Fatigue On Medial Elbow Stability, Nathaniel Harvey Millard

Theses, Dissertations and Capstones

Introduction: The medial elbow is supported from valgus loading with the ulnar collateral ligament (UCL), the flexor pronator mass (FPM), and the radial head. Fatigue of muscle can lead to a decrease in force production. The decrease in force production can lead to a decrease in joint stability. This study tested the effect of fatigue of the FPM muscles on the width of the medial joint space.

Methods: Thirty-one participants volunteered for this study (18 female and 12 male, 1 excluded; mean height 170.2±10.1 cm, mean weight 71.2±15.6 kg, mean age 21.53±1.87 years old). Ultrasound images of the width of …