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Full-Text Articles in Medicine and Health Sciences
Loss Of Glycosaminoglycan Receptor Binding After Mosquito Cell Passage Reduces Chikungunya Virus Infectivity, Amber M. Paul, Dhiraj Acharya, John F. Anderson, Faqing Huang, Fengwei Bai
Loss Of Glycosaminoglycan Receptor Binding After Mosquito Cell Passage Reduces Chikungunya Virus Infectivity, Amber M. Paul, Dhiraj Acharya, John F. Anderson, Faqing Huang, Fengwei Bai
Publications
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that can cause fever and chronic arthritis in humans. CHIKV that is generated in mosquito or mammalian cells differs in glycosylation patterns of viral proteins, which may affect its replication and virulence. Herein, we compare replication, pathogenicity, and receptor binding of CHIKV generated in Vero cells (mammal) or C6/36 cells (mosquito) through a single passage. We demonstrate that mosquito cell derived CHIKV (CHIKVmos) has slower replication than mammalian cell derived CHIKV (CHIKVvero), when tested in both human and murine cell lines. Consistent with this, CHIKVmos infection in both cell lines produce less cytopathic …
Assessing Computer Vision Syndrome Risk For Pilots, Curt Mowry, David C. Ison
Assessing Computer Vision Syndrome Risk For Pilots, Curt Mowry, David C. Ison
Journal of Aviation/Aerospace Education & Research
The purpose of this study was to determine if pilots are at risk for computer vision syndrome (CVS) as computer display technology becomes commonplace in modern cockpits and simulators. A review of computer vision syndrome respect to causes and effects is provided. Display technology used in aircraft and simulators are outlined. Ergonomics and human factors for pilots in aircraft and in simulators are discussed in relation to video displays. A survey of 178 individuals was conducted to determine if there is a statistically significant link between exposure to computer displays and three categories of symptoms of CVS on the flight …