Medicine and Health Sciences Commons^™

Interleukin-16 Rs4778889 Polymorphism And Its Interaction With Interleukin-10 Rs1800896 Polymorphism Increase The Risk For Knee Osteoarthritis In The Lebanese Population, Zeina El-Ali, Fouad Ziade, Hassan Zmerly, Nisrine Bissar

BAU Journal - Health and Wellbeing

To investigate the effect Interleukin-16 (IL-16) and Interleukin-10 (IL-10) polymorphisms, and their interaction, on knee osteoarthritis (KOA) risk in the Lebanese population. Kompetitive Allele Specific PCR (KASP) genotyping assay was performed to determine IL-16 rs4778889, rs11556218, and rs4072111 and IL-10 rs1800896 polymorphisms in 118 patients diagnosed with KOA ( ≥ 2 points on Kellgren-Lawrence (K&L) radiological classification scale) and 70 controls matched for age and gender (K&L score ≤ 1). After adjusting for age, gender, presence of metabolic disorders, smoking and drinking status, our findings suggest that rs4778889 TT genotype increases the risk for KOA compared to the combined CC …