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Articles 1 - 6 of 6
Full-Text Articles in Medicine and Health Sciences
Plasmodium Impairs Antibacterial Innate Immunity To Systemic Infections In Part Through Hemozoin-Bound Bioactive Molecules., Christopher Lynn Harding
Plasmodium Impairs Antibacterial Innate Immunity To Systemic Infections In Part Through Hemozoin-Bound Bioactive Molecules., Christopher Lynn Harding
Electronic Theses and Dissertations
Despite efforts to decrease the global health burden of malaria, infections with Plasmodium species continue to cause over 200 million episodes of malaria each year which resulted in 405,000 deaths in 2018 [1]. One complication of malaria is increased susceptibility to invasive bacterial infections. Plasmodium infections impair host immunity to non-Typhoid Salmonella (NTS) through activities of heme oxygenase I (HO-I) )-induced release of immature granulocytes and myeloid cell-derived IL-10. Yet, it is not known if these mechanisms are specific to NTS. We show here, that Plasmodium yoelii 17XNL (Py) infected mice had impaired clearance of systemic Listeria monocytogenes (Lm) during …
Examination Of Inflammatory Caspase Aggregates Formed In The Presence Of Lipopolysaccharide, Grant D. Andersen
Examination Of Inflammatory Caspase Aggregates Formed In The Presence Of Lipopolysaccharide, Grant D. Andersen
DePaul Discoveries
Inflammatory caspases are involved in the innate immune response, in which cell damage and microorganism invasion lead to cell death via pyroptosis and the release of chemical signals that produce inflammation. Currently, little is known pertaining to the mechanism of activation for one of the major caspase isoforms, caspase-4, other than its ability to bind LPS and become more active because of it. It has been theorized that caspase-4 agregation occurs through a non-cannonical based pathways in forming its respective complex following binding to LPS. Alternatively, caspase-4 may be activated after binding LPS micelles. Herein, we sought to incorporate lipopollysaccharide …
Characterization Of Ncf1 Mutants In A Zebrafish Model Of Innate Immune Function With Human Influenza A Virus Infection, Lily Charpentier
Characterization Of Ncf1 Mutants In A Zebrafish Model Of Innate Immune Function With Human Influenza A Virus Infection, Lily Charpentier
Honors College
Seasonal influenza A virus (IAV) infections and their associated respiratory diseases are the cause of an estimated 650,000 deaths each year, according to the World Health Organization. The zebrafish (Danio rerio) is a powerful vertebrate model to study innate immune function and host-pathogen interactions as the function of neutrophils and other phagocytes can be characterized in vivo. Preliminary studies have shown an increase in neutrophil respiratory burst activity to eliminate the invading pathogen, yet little is known of all of the mechanisms involved in neutrophil function. The NADPH oxidase complex, of which neutrophil cytosolic factor 1 (Ncf1) is a key …
In Vivo Imaging Of The Respiratory Burst Response To Influenza A Virus Infection, James Thomas Seuch
In Vivo Imaging Of The Respiratory Burst Response To Influenza A Virus Infection, James Thomas Seuch
Honors College
The CDC estimated that seasonal influenza A virus (IAV) infections resulted in 490,600 hospitalizations and 34,200 deaths in the US in the 2018-2019 season. The longterm goal of our research is to understand how to improve innate immune responses to IAV. During IAV infection, neutrophils and macrophages initiate a respiratory burst response where reactive oxygen species (ROS) are generated to destroy the pathogen and recruit additional immune cells. While ROS molecules, such as hydrogen peroxide, help clear the virus, the signaling cascade can also lead to excess neutrophil recruitment, hyperinflammation, and tissue damage. Regulatory mechanisms that trigger overactivation of neutrophils …
Biological Sex Influences Susceptibility To Acinetobacter Baumannii Pneumonia In Mice, Sílvia Pires, Adeline Peignier, Jeremy Seto, Davida S. Smyth, Dane Parker
Biological Sex Influences Susceptibility To Acinetobacter Baumannii Pneumonia In Mice, Sílvia Pires, Adeline Peignier, Jeremy Seto, Davida S. Smyth, Dane Parker
Publications and Research
Acinetobacter baumannii (A. baumannii) is an extremely versatile multidrug-resistant pathogen with a very high mortality rate; therefore, it has become crucial to understand the host response during its infection. Given the importance of mice for modeling infection and their role in preclinical drug development, equal emphasis should be placed on the use of both sexes. Through our studies using a murine model of acute pneumonia with A. baumannii, we observed that female mice were more susceptible to infection. Likewise, treatment of male mice with estradiol increased their susceptibility to infection. Analysis of the airway compartment revealed enhanced inflammation and reduced …
The Effect Of Staphylococcus Aureus Extracellular Products (Secp) On Performance,Selective Innate Immune Indexes, And Humoral Immune Response Against Avian Influenzaand Newcastle Disease Vaccines In Broiler Chickens, Teimour Tabari, Younes Papi, Esmaeil Azizi, Forough Talazadeh, Ramezan Ali Jafari, Masoud Ghorbanpoor
The Effect Of Staphylococcus Aureus Extracellular Products (Secp) On Performance,Selective Innate Immune Indexes, And Humoral Immune Response Against Avian Influenzaand Newcastle Disease Vaccines In Broiler Chickens, Teimour Tabari, Younes Papi, Esmaeil Azizi, Forough Talazadeh, Ramezan Ali Jafari, Masoud Ghorbanpoor
Turkish Journal of Veterinary & Animal Sciences
Improving the immune response is important for many reasons such as vaccine failure, immunosuppressive diseases, and antibiotics misuse. Research on materials likely to have immune-enhancing effects has been on the rise. Factors, substances, or compounds that can regulate different functions of the immune system can be used to enhance specific and even nonspecific responses to vaccines. Different amounts (0, 25, 50, and 100 μg) of Staphylococcus aureus extracellular products (SECP) were injected subcutaneously to different groups of chickens during the first vaccination against avian influenza (AI) and Newcastle disease (ND) viruses to investigate the effect of SECP on innate and …