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Full-Text Articles in Medicine and Health Sciences
Quantifying The Heterogeneity Of The Immunoglobulin G N-Glycome In An Ageing Australian Population: The Busselton Healthy Ageing Study, Alyce Russell
Quantifying The Heterogeneity Of The Immunoglobulin G N-Glycome In An Ageing Australian Population: The Busselton Healthy Ageing Study, Alyce Russell
Theses: Doctorates and Masters
The use of immunoglobulin G N-glycomics to study chronic non-communicable disorders and other complex phenotypes emerged following the Human Genome Project. The consortium discovered that most phenotypes were too complex to be explained by genetics alone. Thus, the biological importance of epigenetics was recognised; heritable modifications to gene expression rather than the genome itself. Nglycosylation is a form of epigenetic regulation known as a post-translational modification. It stabilises the immunoglobulin G structure and alters downstream responses elicited by the antibody and is extensively studied as a candidate biomarker in the post-genomic era.
The N-glycosylation of immunoglobulin G itself is complex, …
Association Between Pelvic Inflammatory Disease, Infertility, Ectopic Pregnancy And The Development Of Ovarian Serous Borderline Tumor, Mucinous Borderline Tumor And Low-Grade Serous Carcinoma, Louise Stewart, C J.R Stewart, Katrina Spilsbury, P A. Cohen, S Jordan
Association Between Pelvic Inflammatory Disease, Infertility, Ectopic Pregnancy And The Development Of Ovarian Serous Borderline Tumor, Mucinous Borderline Tumor And Low-Grade Serous Carcinoma, Louise Stewart, C J.R Stewart, Katrina Spilsbury, P A. Cohen, S Jordan
IHR Papers and Journal Articles
Objective: Risk factors for ovarian borderline tumors and low-grade serous carcinoma (LGSC) are poorly understood. The aim of this study was to examine the association between infertility, pelvic inflammatory disease (PID), endometriosis, ectopic pregnancy, hysterectomy, tubal ligation and parity and the risk of serous borderline tumor (SBT), mucinous borderline tumor (MBT) and LGSC.
Methods: This was a population-based cohort study using linked administrative and hospital data. Participants were 441,382 women born between 1945 and 1975 who had been admitted to hospital in Western Australia between 1 January 1980 and 30 June 2014. We used Cox regression to estimate hazard ratios …