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Articles 1 - 12 of 12
Full-Text Articles in Medicine and Health Sciences
Chronic Muscle Weakness And Mitochondrial Dysfunction In The Absence Of Sustained Atrophy In A Preclinical Sepsis Model, Allison M. Owen, Samir P. Patel, Jeffrey D. Smith, Beverly K. Balasuriya, Stephanie F. Mori, Gregory S. Hawk, Arnold J. Stromberg, Naohide Kuriyama, Masao Kaneki, Alexander G. Rabchevsky, Timothy A. Butterfield, Karyn A. Esser, Charlotte A. Peterson, Marlene E. Starr, Hiroshi Saito
Chronic Muscle Weakness And Mitochondrial Dysfunction In The Absence Of Sustained Atrophy In A Preclinical Sepsis Model, Allison M. Owen, Samir P. Patel, Jeffrey D. Smith, Beverly K. Balasuriya, Stephanie F. Mori, Gregory S. Hawk, Arnold J. Stromberg, Naohide Kuriyama, Masao Kaneki, Alexander G. Rabchevsky, Timothy A. Butterfield, Karyn A. Esser, Charlotte A. Peterson, Marlene E. Starr, Hiroshi Saito
Physiology Faculty Publications
Chronic critical illness is a global clinical issue affecting millions of sepsis survivors annually. Survivors report chronic skeletal muscle weakness and development of new functional limitations that persist for years. To delineate mechanisms of sepsis-induced chronic weakness, we first surpassed a critical barrier by establishing a murine model of sepsis with ICU-like interventions that allows for the study of survivors. We show that sepsis survivors have profound weakness for at least 1 month, even after recovery of muscle mass. Abnormal mitochondrial ultrastructure, impaired respiration and electron transport chain activities, and persistent protein oxidative damage were evident in the muscle of …
Expression And Function Of Snornas In Acute Myeloid Leukemia, Wayne Alsworth Warner
Expression And Function Of Snornas In Acute Myeloid Leukemia, Wayne Alsworth Warner
Arts & Sciences Electronic Theses and Dissertations
Small nucleolar RNAs (snoRNAs) are non-coding RNAs that contribute to ribosome biogenesis and RNA splicing by modifying ribosomal RNA and spliceosome RNAs, respectively. These modifications are critical for a variety of cellular processes, including ribosomal biogenesis and splicing of RNAs. Recent studies have suggested an expanded role for snoRNAs beyond ribosomal biogenesis and splicing, including, regulation of chromatin structure, metabolism, and neoplastic transformation. The contribution of snoRNAs to the regulation of normal and malignant hematopoiesis is largely unknown. The lack of a method to accurately and comprehensively assess snoRNA expression has limited research in this area. In particular, array-based methods …
Predicting Tgf-Β-Induced Epithelial-Mesenchymal Transition Using Data Assimilation, Mario J. Mendez, Matthew J. Hoffman, Elizabeth M. Cherry, Dr. Christopher Lemmon, Seth Weinberg
Predicting Tgf-Β-Induced Epithelial-Mesenchymal Transition Using Data Assimilation, Mario J. Mendez, Matthew J. Hoffman, Elizabeth M. Cherry, Dr. Christopher Lemmon, Seth Weinberg
Biology and Medicine Through Mathematics Conference
No abstract provided.
Quantifying Differences In The Interferon Signaling Network Across Cell Types, Sivan Leviyang, Igor Griva, Nate Strawn
Quantifying Differences In The Interferon Signaling Network Across Cell Types, Sivan Leviyang, Igor Griva, Nate Strawn
Biology and Medicine Through Mathematics Conference
No abstract provided.
Early Events During Hepatitis B Virus Infections, Stanca Ciupe
Early Events During Hepatitis B Virus Infections, Stanca Ciupe
Biology and Medicine Through Mathematics Conference
No abstract provided.
Mathematical Modeling Of Left Ventricular Remodeling Post-Myocardial Infarction With And Without Treatment, Mehtap Lafci
Mathematical Modeling Of Left Ventricular Remodeling Post-Myocardial Infarction With And Without Treatment, Mehtap Lafci
Biology and Medicine Through Mathematics Conference
No abstract provided.
Age Dependent Regulation Of Cardiac Sodium Channel Gain Of Function, Madison Nowak, David Ryan King, Steven Poelzing, Seth Weinberg
Age Dependent Regulation Of Cardiac Sodium Channel Gain Of Function, Madison Nowak, David Ryan King, Steven Poelzing, Seth Weinberg
Biology and Medicine Through Mathematics Conference
No abstract provided.
Robust Estimation For Factor Loadings With Application To Postpartum Depression, Kenneth Nieser
Robust Estimation For Factor Loadings With Application To Postpartum Depression, Kenneth Nieser
Biology and Medicine Through Mathematics Conference
No abstract provided.
Development Of A Mathematical Model For The Role Of Inflammation In Atherosclerosis, Marcella Torres, Jing Wang, Paul J. Yannie, Shobha Ghosh, Rebecca Segal, Angela Reynolds
Development Of A Mathematical Model For The Role Of Inflammation In Atherosclerosis, Marcella Torres, Jing Wang, Paul J. Yannie, Shobha Ghosh, Rebecca Segal, Angela Reynolds
Biology and Medicine Through Mathematics Conference
No abstract provided.
Understanding Toxin Production During Clostridioides Difficile Infection Using High Dimensional Data, Samantha Erwin, Joshua R. Fletcher, Casey M. Theriot, Cristina Lanzas
Understanding Toxin Production During Clostridioides Difficile Infection Using High Dimensional Data, Samantha Erwin, Joshua R. Fletcher, Casey M. Theriot, Cristina Lanzas
Biology and Medicine Through Mathematics Conference
No abstract provided.
Parameter Identifiability Of A Dynamical System Model Of Breathing In A Preterm Infant, Laura Ellwein Fix, Henry Rozycki
Parameter Identifiability Of A Dynamical System Model Of Breathing In A Preterm Infant, Laura Ellwein Fix, Henry Rozycki
Biology and Medicine Through Mathematics Conference
No abstract provided.
Role Of Dyslipidemia On Lipid Metabolism In Maintenance Hemodialysis Patients, Eno Latifi
Role Of Dyslipidemia On Lipid Metabolism In Maintenance Hemodialysis Patients, Eno Latifi
Wayne State University Dissertations
Maintenance hemodialysis (MHD) patients experience various abnormalities such as systemic inflammation (SI), oxidative stress (OS), and dyslipidemia (D). Defined as an imbalance of plasma lipids, lipoproteins, and lipid metabolism enzymes, D has been associated with a rise in morbidity and mortality within ESRD patients due to cardiovascular disease (CVD). However, the contribution of each of these parameters to D is poorly understood; moreover, the impact of the following parameters on dyslipidemia in different ethnicities is unknown. Hence, the objective of this study was to characterize D in a multi-ethnic cohort of ESRD patients. We hypothesized that the degree of dyslipidemia …