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Full-Text Articles in Medicine and Health Sciences
Investigating Checkpoint Kinases 1/2 As Novel Therapeutic Targets In Head And Neck Squamous Cell Carcinoma, Mayur Arvind Gadhikar
Investigating Checkpoint Kinases 1/2 As Novel Therapeutic Targets In Head And Neck Squamous Cell Carcinoma, Mayur Arvind Gadhikar
Dissertations & Theses (Open Access)
Cisplatin, despite being the cornerstone chemotherapy for the treatment of head and neck squamous cell carcinoma (HNSCC), provides clinical benefits in just a subset of patients. This together with the lack of biomarkers predicting therapeutic responses, have led to unacceptably high rate of treatment failures in HNSCC. TP53 is the most frequently mutated gene in HNSCC, and the effect of p53 loss or mutation on cisplatin responses in HNSCC is poorly understood. In the current study, we hypothesized that HNSCC cells respond to cisplatin in a p53 dependent manner and unambiguously show that presence of wild-type TP53 (wtp53) confers sensitivity …
Targeting The Mdm2-P53 Axis For The Treatment Of Dedifferentiated Liposarcoma, Katelynn Bill
Targeting The Mdm2-P53 Axis For The Treatment Of Dedifferentiated Liposarcoma, Katelynn Bill
Dissertations & Theses (Open Access)
Dedifferentiated liposarcoma (DDLPS) is an aggressive malignancy characterized by a high rate of recurrence and dismal patient outcome. Minimal improvement in patient survival has been made in the last several decades, highlighting the crucial need for improved therapeutic strategies. A better understanding of the molecular deregulations underlying DDLPS would facilitate the discovery of improved therapeutic approaches. MDM2 is a well characterized oncoprotein and the most known negative regulator of p53. MDM2 amplification is considered the “hallmark” of DDLPS. Additionally, these tumors are known to harbor wild-type p53. We sought to take advantage of this knowledge and evaluate the role of …
Isolation And Characterization Of Multipotent Lung Stem Cells From P53 Mutant Mice Models, Venkat Sundar Gadepalli
Isolation And Characterization Of Multipotent Lung Stem Cells From P53 Mutant Mice Models, Venkat Sundar Gadepalli
Theses and Dissertations
Recent advances in understanding lung biology have shown evidence for the existence of resident lung stem cells. Independent studies in identifying and characterizing these somatic lung stem cells have shown the potential role of these cells in lung repair and regeneration. Understanding the functional characteristics of these tissue resident stem/progenitor cells has gained much importance with increasing evidence of cancer stem cells, cells in a tumor tissue with stem cell characteristics. Lung cancer is most commonly characterized by loss of p53 function which results in uncontrolled cell divisions. Incidence of p53 point mutations is highest in lung cancer, with a …