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Full-Text Articles in Medicine and Health Sciences
Regulation Of Lipid Homeostasis, Inflammatory Signalling And Atherosclerosis By The Peroxisome Proliferator-Activated Receptor Delta, Lazar A. Bojic
Regulation Of Lipid Homeostasis, Inflammatory Signalling And Atherosclerosis By The Peroxisome Proliferator-Activated Receptor Delta, Lazar A. Bojic
Electronic Thesis and Dissertation Repository
The peroxisome proliferator-activated receptor (PPAR) δ is a ligand-dependent transcription factor that has been implicated in metabolic and inflammatory regulation. The molecular and physiological mechanisms by which PPARδ activation regulates lipid metabolism, inflammatory signaling and protection from atherosclerosis in states of metabolic disturbance such as insulin resistance and dyslipidemia, were investigated in a series of in vitro and in vivo studies. In vitro experiments demonstrated that PPARδ activation inhibits atherogenic lipoprotein-induced lipid accumulation and the associated proinflammatory responses. The primary mechanisms for these effects were increased fatty acid β-oxidation, decreased lipoprotein lipase (LPL) activity, reduced MAPK signaling and improved insulin …
Investigation Of Web-Based Motivational Interviewing To Increase Physical Activity Participation Among Adults, Sasha Karnes
Investigation Of Web-Based Motivational Interviewing To Increase Physical Activity Participation Among Adults, Sasha Karnes
Theses and Dissertations
Interventions to enhance physical activity (PA) participation are needed given the high prevalence of under-activity and inactivity (CDC, 2001) and related occurrence of negative health consequences among the general adult population (Kung, Hoyert, Xu, & Murphy, 2008). Preliminary support for a therapeutic technique called Motivational Interviewing (MI) suggests promise for application to enhance PA participation (Burke, Arkowitz, & Menchola, 2003). Given the need for interventions to enhance PA and the preliminary support for MI as an intervention to increase PA, the aims of the current study were to: (a) determine if web-based MI is effective in enhancing PA participation, and …