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Matriptase Mediated C-Met Signaling In Breast Cancer, Gina Lynn Zoratti
Matriptase Mediated C-Met Signaling In Breast Cancer, Gina Lynn Zoratti
Wayne State University Dissertations
MATRIPTASE MEDIATED c-MET SIGNALING IN CRITICAL FOR BREAST CANCER PROGRESSION
by
GINA ZORATTI
Historically proteases have been associated with tumor progression and metastasis through degradation of the basement membrane. However, in recent years these enzymes have also been shown to play key roles in the activation of growth factors and cytokines, thereby activating pro-oncogenic signaling pathways. Matriptase (MT-SP1, ST14) is an epithelia-specific pericellular protease which has received considerable attention in recent years spurred by the consistent dysregulation of the protease in human epithelial tumors including breast cancer. We have performed both functional and mechanistic studies of matriptase in breast cancer …